Roshni received her postdoctoral training at Stanford University under the guidance of Prof. Yueh-hsiu Chien and holds a PhD in Immunology from Indiana State University. Throughout her postdoctoral research, Roshni used multi-dimensional, high-throughput systems biology approaches to study the immunopathogenic processes underlying tuberculosis infection, food allergies, and cardiovascular disease. As an independent investigator, she now aims to harness such integrative systems approaches to study the underlying biology of tissue-localized immunity to address the unmet clinical needs associated with tissue pathologies. She is specifically interested in unconventional lymphocytes (CD4-CD8- DN alpha beta T cells, CD8+ gamma delta T cells, and CD5+ B cells) and understanding the functional consequences of their enrichment in different tissue localizations in humans.
NK-like CD8+ ?d T cells are expanded in persistent Mycobacterium tuberculosis infection.
NK-like CD8+ ?d T cells are expanded in persistent Mycobacterium tuberculosis infection. Sci Immunol. 2023 03 31; 8(81):eade3525.
PMID: 37000856
Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self.
Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self. Circ Res. 2022 05 13; 130(10):1510-1530.
PMID: 35430876
Immune changes beyond Th2 pathways during rapid multifood immunotherapy enabled with omalizumab.
Immune changes beyond Th2 pathways during rapid multifood immunotherapy enabled with omalizumab. Allergy. 2021 09; 76(9):2809-2826.
PMID: 33782956
Select sequencing of clonally expanded CD8+ T cells reveals limits to clonal expansion.
Select sequencing of clonally expanded CD8+ T cells reveals limits to clonal expansion. Proc Natl Acad Sci U S A. 2019 04 30; 116(18):8995-9001.
PMID: 30992377
Author Correction: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes.
Author Correction: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes. Nature. 2018 12; 564(7734):E5.
PMID: 30377311
A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes.
A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes. Nature. 2018 08; 560(7720):644-648.
PMID: 30135583
Efficacy of phytol-derived diterpenoid immunoadjuvants over alum in shaping the murine host's immune response to Staphylococcus aureus.
Efficacy of phytol-derived diterpenoid immunoadjuvants over alum in shaping the murine host's immune response to Staphylococcus aureus. Vaccine. 2013 Feb 06; 31(8):1178-86.
PMID: 23313815
Synthetic adjuvants for vaccine formulations: phytol derivatives.
Synthetic adjuvants for vaccine formulations: phytol derivatives. Expert Opin Drug Deliv. 2013 Apr; 10(4):437-50.
PMID: 23293963
Effects of small intestinal submucosa (SIS) on the murine innate immune microenvironment induced by heat-killed Staphylococcus aureus.
Effects of small intestinal submucosa (SIS) on the murine innate immune microenvironment induced by heat-killed Staphylococcus aureus. PLoS One. 2012; 7(11):e48724.
PMID: 23189134
Phytol-derived novel isoprenoid immunostimulants.
Phytol-derived novel isoprenoid immunostimulants. Front Immunol. 2012; 3:49.
PMID: 22566931