Nicolas chevrier

Assistant Professor
Websites
Research Summary
Our research aims to uncover the grammar – or general rules – governing how successful immune responses work to stop an infection or remove diseased cells while keeping the host healthy at the end of the process. We emphasize a multiscale approach that parallels the organization of the immune system across the body from molecules and cells to tissues to the whole organism. By creating new tools and approaches, we study how interactions occur between immunological components across these scales to uncover fundamental concepts in immunology and beyond. We pursue this goal in the hope that it will contribute knowledge to the longstanding question of how to manipulate the immune system at will.
Education
  • Harvard Medical School, Boston, USA, Ph.D. Immunology 06/2012
  • Université de la Méditerranée, Marseille, France, M.S. Biochemistry, Immunology 06/2007
  • Université de Bourgogne, Dijon, France, B.S. Biochemistry 06/2005
Biosciences Graduate Program Association
Publications
  1. Aaboud M, Aad G, Abbott B, Abdallah J, Abdinov O, Abeloos B, Aben R, AbouZeid OS, Abraham NL, Abramowicz H, Abreu H, Abreu R, Abulaiti Y, Acharya BS, Adachi S, Adamczyk L, Adams DL, Adelman J, Adomeit S, Adye T, Affolder AA, Agatonovic-Jovin T, Aguilar-Saavedra JA, Ahlen SP, Ahmadov F, Aielli G, Akerstedt H, Åkesson TPA, Akimov AV, Alberghi GL, Albert J, Albrand S, Alconada Verzini MJ, Aleksa M, Aleksandrov IN, Alexa C, Alexander G, Alexopoulos T, Alhroob M, Ali B, Aliev M, Alimonti G, Alison J, Alkire SP, Allbrooke BMM, Allen BW, Allport PP, Aloisio A, Alonso A, Alonso F, Alpigiani C, Alshehri AA, Alstaty M, Alvarez Gonzalez B, Álvarez Piqueras D, Alviggi MG, Amadio BT, Amaral Coutinho Y, Amelung C, Amidei D, Amor Dos Santos SP, Amorim A, Amoroso S, Amundsen G, Anastopoulos C, Ancu LS, Andari N, Andeen T, Anders CF, Anders G, Anders JK, Anderson KJ, Andreazza A, Andrei V, Angelidakis S, Angelozzi I, Angerami A, Anghinolfi F, Anisenkov AV, Anjos N, Annovi A, Antel C, Antonelli M, Antonov A, Antrim DJ, Anulli F, Aoki M, Aperio Bella L, Arabidze G, Arai Y, Araque JP, Arce ATH, Arduh FA, Arguin JF, Argyropoulos S, Arik M, Armbruster AJ, Armitage LJ, Arnaez O, Arnold H, Arratia M, Arslan O, Artamonov A, Artoni G, Artz S, Asai S, Asbah N, Ashkenazi A, Åsman B, Asquith L, Assamagan K, Astalos R, Atkinson M, Atlay NB, Augsten K, Avolio G, Axen B, Ayoub MK, Azuelos G, Baak MA, Baas AE, Baca MJ, Bachacou H, Bachas K, Backes M, Backhaus M, Bagiacchi P, Bagnaia P, Bai Y, Baines JT, Bajic M, Baker OK, Baldin EM, Balek P, Balestri T, Balli F, Balunas WK, Banas E, Banerjee S, Bannoura AAE, Barak L, Barberio EL, Barberis D, Barbero M, Barillari T, Barisits MS, Barklow T, Barlow N, Barnes SL, Barnett BM, Barnett RM, Barnovska-Blenessy Z, Baroncelli A, Barone G, Barr AJ, Barranco Navarro L, Barreiro F, da Costa JBG, Bartoldus R, Barton AE, Bartos P, Basalaev A, Bassalat A, Bates RL, Batista SJ, Batley JR, Battaglia M, Bauce M, Bauer F, Bawa HS, Beacham JB, Beattie MD, Beau T, Beauchemin PH, Bechtle P, Beck HP, Becker K, Becker M, Beckingham M, Becot C, Beddall AJ, Beddall A, Bednyakov VA, Bedognetti M, Bee CP, Beemster LJ, Beermann TA, Begel M, Behr JK, Bell AS, Bella G, Bellagamba L, Bellerive A, Bellomo M, Belotskiy K, Beltramello O, Belyaev NL, Benary O, Benchekroun D, Bender M, Bendtz K, Benekos N, Benhammou Y, Benhar Noccioli E, Benitez J, Benjamin DP, Bensinger JR, Bentvelsen S, Beresford L, Beretta M, Berge D, Bergeaas Kuutmann E, Berger N, Beringer J, Berlendis S, Bernard NR, Bernius C, Bernlochner FU, Berry T, Berta P, Bertella C, Bertoli G, Bertolucci F, Bertram IA, Bertsche C, Bertsche D, Besjes GJ, Bessidskaia Bylund O, Bessner M, Besson N, Betancourt C, Bethani A, Bethke S, Bevan AJ, Bianchi RM, Bianco M, Biebel O, Biedermann D, Bielski R, Biesuz NV, Biglietti M, De Mendizabal JB, Billoud TRV, Bilokon H, Bindi M, Binet S, Bingul A, Bini C, Biondi S, Bisanz T, Bjergaard DM, Black CW, Black JE, Black KM, Blackburn D, Blair RE, Blazek T, Bloch I, Blocker C, Blue A, Blum W, Blumenschein U, Blunier S, Bobbink GJ, Bobrovnikov VS, Bocchetta SS, Bocci A, Bock C, Boehler M, Boerner D, Bogaerts JA, Bogavac D, Bogdanchikov AG, Bohm C, Boisvert V, Bokan P, Bold T, Boldyrev AS, Bomben M, Bona M, Boonekamp M, Borisov A, Borissov G, Bortfeldt J, Bortoletto D, Bortolotto V, Bos K, Boscherini D, Bosman M, Bossio Sola JD, Boudreau J, Bouffard J, Bouhova-Thacker EV, Boumediene D, Bourdarios C, Boutle SK, Boveia A, Boyd J, Boyko IR, Bracinik J, Brandt A, Brandt G, Brandt O, Bratzler U, Brau B, Brau JE, Breaden Madden WD, Brendlinger K, Brennan AJ, Brenner L, Brenner R, Bressler S, Bristow TM, Britton D, Britzger D, Brochu FM, Brock I, Brock R, Brooijmans G, Brooks T, Brooks WK, Brosamer J, Brost E, Broughton JH, de Renstrom PAB, Bruncko D, Bruneliere R, Bruni A, Bruni G, Bruni LS, Brunt BH, Bruschi M, Bruscino N, Bryant P, Bryngemark L, Buanes T, Buat Q, Buchholz P, Buckley AG, Budagov IA, Buehrer F, Bugge MK, Bulekov O, Bullock D, et al. Measurement of the prompt J/[Formula: see text] pair production cross-section in pp collisions at [Formula: see text] TeV with the ATLAS detector. Eur Phys J C Part Fields. 2017; 77(2):76. View in: PubMed

  2. Chevrier N. Decoding the Body Language of Immunity: Tackling the Immune System at the Organism Level. Curr Opin Syst Biol. 2019 Dec; 18:19-26. View in: PubMed

  3. Pandey S, Takahama M, Gruenbaum A, Zewde M, Cheronis K, Chevrier N. A whole-tissue RNA-seq toolkit for organism-wide studies of gene expression with PME-seq. Nat Protoc. 2020 04; 15(4):1459-1483. View in: PubMed

  4. Kadoki M, Patil A, Thaiss CC, Brooks DJ, Pandey S, Deep D, Alvarez D, von Andrian UH, Wagers AJ, Nakai K, Mikkelsen TS, Soumillon M, Chevrier N. Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues. Cell. 2017 Oct 05; 171(2):398-413.e21. View in: PubMed

  5. Mertins P, Przybylski D, Yosef N, Qiao J, Clauser K, Raychowdhury R, Eisenhaure TM, Maritzen T, Haucke V, Satoh T, Akira S, Carr SA, Regev A, Hacohen N, Chevrier N. An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Cell Rep. 2017 06 27; 19(13):2853-2866. View in: PubMed

  6. Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH. Suppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016 Dec; 17(12):1436-1446. View in: PubMed

  7. Mostafavi S, Yoshida H, Moodley D, LeBoité H, Rothamel K, Raj T, Ye CJ, Chevrier N, Zhang SY, Feng T, Lee M, Casanova JL, Clark JD, Hegen M, Telliez JB, Hacohen N, De Jager PL, Regev A, Mathis D, Benoist C. Parsing the Interferon Transcriptional Network and Its Disease Associations. Cell. 2016 Jan 28; 164(3):564-78. View in: PubMed

  8. Jovanovic M, Rooney MS, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach MR, Eisenhaure T, Rabani M, Gennert D, Lu D, Delorey T, Weissman JS, Carr SA, Hacohen N, Regev A. Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens. Science. 2015 Mar 06; 347(6226):1259038. View in: PubMed

  9. Tonti E, Jiménez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, Iannacone M. Bisphosphonates target B cells to enhance humoral immune responses. Cell Rep. 2013 Oct 31; 5(2):323-30. View in: PubMed

  10. Gat-Viks I, Chevrier N, Wilentzik R, Eisenhaure T, Raychowdhury R, Steuerman Y, Shalek AK, Hacohen N, Amit I, Regev A. Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli. Nat Biotechnol. 2013 Apr; 31(4):342-9. View in: PubMed

  11. Salcedo SP, Chevrier N, Lacerda TL, Ben Amara A, Gerart S, Gorvel VA, de Chastellier C, Blasco JM, Mege JL, Gorvel JP. Pathogenic brucellae replicate in human trophoblasts. J Infect Dis. 2013 Apr; 207(7):1075-83. View in: PubMed

  12. Shalek AK, Gaublomme JT, Wang L, Yosef N, Chevrier N, Andersen MS, Robinson JT, Pochet N, Neuberg D, Gertner RS, Amit I, Brown JR, Hacohen N, Regev A, Wu CJ, Park H. Nanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia. . 2012 Dec 12; 12(12):6498-504. View in: PubMed

  13. Garber M, Yosef N, Goren A, Raychowdhury R, Thielke A, Guttman M, Robinson J, Minie B, Chevrier N, Itzhaki Z, Blecher-Gonen R, Bornstein C, Amann-Zalcenstein D, Weiner A, Friedrich D, Meldrim J, Ram O, Cheng C, Gnirke A, Fisher S, Friedman N, Wong B, Bernstein BE, Nusbaum C, Hacohen N, Regev A, Amit I. A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell. 2012 Sep 14; 47(5):810-22. View in: PubMed

  14. Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu YX, Hacohen N, von Andrian UH. B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity. 2012 Mar 23; 36(3):415-26. View in: PubMed

  15. Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H, Carr SA, Regev A, Amit I, Hacohen N. Systematic discovery of TLR signaling components delineates viral-sensing circuits. Cell. 2011 Nov 11; 147(4):853-67. View in: PubMed

  16. Guia S, Jaeger BN, Piatek S, Mailfert S, Trombik T, Fenis A, Chevrier N, Walzer T, Kerdiles YM, Marguet D, Vivier E, Ugolini S. Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance. Sci Signal. 2011 Apr 05; 4(167):ra21. View in: PubMed

  17. Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M, Grenier JK, Li W, Zuk O, Schubert LA, Birditt B, Shay T, Goren A, Zhang X, Smith Z, Deering R, McDonald RC, Cabili M, Bernstein BE, Rinn JL, Meissner A, Root DE, Hacohen N, Regev A. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science. 2009 Oct 09; 326(5950):257-63. View in: PubMed

  18. Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira S. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol. 2006 Aug; 7(8):868-74. View in: PubMed