Nicolas chevrier | Committee on Immunology

Research Summary

Our research aims to uncover the grammar – or general rules – governing how successful immune responses work to stop an infection or remove diseased cells while keeping the host healthy at the end of the process. We emphasize a multiscale approach that parallels the organization of the immune system across the body from molecules and cells to tissues to the whole organism. By creating new tools and approaches, we study how interactions occur between immunological components across these scales to uncover fundamental concepts in immunology and beyond. We pursue this goal in the hope that it will contribute knowledge to the longstanding question of how to manipulate the immune system at will.

Education

Harvard Medical School, Boston, USA, Ph.D. Immunology 06/2012
Université de la Méditerranée, Marseille, France, M.S. Biochemistry, Immunology 06/2007
Université de Bourgogne, Dijon, France, B.S. Biochemistry 06/2005

Biosciences Graduate Program Association

Publications

Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation. bioRxiv. 2023 Feb 02. View in: PubMed
Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids unveils masked epitopes in live neurons. Nat Commun. 2021 11 18; 12(1):6715. View in: PubMed
Pairwise Stimulations of Pathogen-Sensing Pathways Predict Immune Responses to Multi-adjuvant Combinations. Cell Syst. 2020 11 18; 11(5):495-508.e10. View in: PubMed
Decoding the Body Language of Immunity: Tackling the Immune System at the Organism Level. Curr Opin Syst Biol. 2019 Dec; 18:19-26. View in: PubMed
A whole-tissue RNA-seq toolkit for organism-wide studies of gene expression with PME-seq. Nat Protoc. 2020 04; 15(4):1459-1483. View in: PubMed
Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues. Cell. 2017 Oct 05; 171(2):398-413.e21. View in: PubMed
An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Cell Rep. 2017 06 27; 19(13):2853-2866. View in: PubMed
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016 Dec; 17(12):1436-1446. View in: PubMed
Parsing the Interferon Transcriptional Network and Its Disease Associations. Cell. 2016 Jan 28; 164(3):564-78. View in: PubMed
Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens. Science. 2015 Mar 06; 347(6226):1259038. View in: PubMed
Bisphosphonates target B cells to enhance humoral immune responses. Cell Rep. 2013 Oct 31; 5(2):323-30. View in: PubMed
Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli. Nat Biotechnol. 2013 Apr; 31(4):342-9. View in: PubMed
Pathogenic brucellae replicate in human trophoblasts. J Infect Dis. 2013 Apr; 207(7):1075-83. View in: PubMed
Nanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia. Nano Lett. 2012 Dec 12; 12(12):6498-504. View in: PubMed
A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell. 2012 Sep 14; 47(5):810-22. View in: PubMed
B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity. 2012 Mar 23; 36(3):415-26. View in: PubMed
Systematic discovery of TLR signaling components delineates viral-sensing circuits. Cell. 2011 Nov 11; 147(4):853-67. View in: PubMed
Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance. Sci Signal. 2011 Apr 05; 4(167):ra21. View in: PubMed
Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science. 2009 Oct 09; 326(5950):257-63. View in: PubMed
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol. 2006 Aug; 7(8):868-74. View in: PubMed