Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.
University of Chicago
Chicago
Post-doc - Functional Genomics
2011
University of Paris VII
Paris
PhD - Population Genetics
2008
Lusófona University
Lisbon
Master - Biotechnological Engineering
2003
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients.
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients. Nat Commun. 2026 Apr 28; 17(1).
PMID: 42049757
Continuous antiretroviral therapy induces progressive senescence-like reprogramming of alveolar macrophages.
Continuous antiretroviral therapy induces progressive senescence-like reprogramming of alveolar macrophages. Front Immunol. 2026; 17:1805936.
PMID: 42099614
Molecular and cellular bases of trained immunity.
Molecular and cellular bases of trained immunity. Immunity. 2026 Apr 14; 59(4):897-910.
PMID: 41985444
Adaptive immune responses to vaccination reflect social status at first exposure in female rhesus macaques.
Adaptive immune responses to vaccination reflect social status at first exposure in female rhesus macaques. bioRxiv. 2026 Mar 05.
PMID: 41847028
Written in our genes, epigenetically edited by infection.
Written in our genes, epigenetically edited by infection. Nat Genet. 2026 Feb; 58(2):243-244.
PMID: 41593235
Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts.
Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts. Cell Genom. 2026 Jan 14; 6(1):101061.
PMID: 41218612
Rewiring the bone marrow: Evolution and the transcriptional architecture of trained immunity.
Rewiring the bone marrow: Evolution and the transcriptional architecture of trained immunity. Elife. 2025 Oct 24; 14.
PMID: 41134297
Author Correction: ß-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus.
Author Correction: ß-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus. Nat Immunol. 2025 Mar; 26(3):525.
PMID: 39920361
Reply to: Insufficient evidence for natural selection associated with the Black Death.
Reply to: Insufficient evidence for natural selection associated with the Black Death. Nature. 2025 Feb; 638(8051):E23-E29.
PMID: 39972229
ß-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus.
ß-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus. Nat Immunol. 2025 Feb; 26(2):174-187.
PMID: 39779870