Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.
University of Chicago
Chicago
Post-doc - Functional Genomics
2011
University of Paris VII
Paris
PhD - Population Genetics
2008
Lusófona University
Lisbon
Master - Biotechnological Engineering
2003
Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination.
Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination. Immunol Lett. 2024 Mar 11; 267:106851.
PMID: 38479480
EpiVar browser: advanced exploration of epigenomics data under controlled access.
EpiVar browser: advanced exploration of epigenomics data under controlled access. Bioinformatics. 2024 Mar 06.
PMID: 38449289
Epigenetic variation impacts individual differences in the transcriptional response to influenza infection.
Epigenetic variation impacts individual differences in the transcriptional response to influenza infection. Nat Genet. 2024 Mar; 56(3):408-419.
PMID: 38424460
DNA methylation-environment interactions in the human genome.
DNA methylation-environment interactions in the human genome. Elife. 2024 Feb 26; 12.
PMID: 38407202
Microbial transmission in the social microbiome and host health and disease.
Microbial transmission in the social microbiome and host health and disease. Cell. 2024 01 04; 187(1):17-43.
PMID: 38181740
The evolutionary tale of lactase persistence in humans.
The evolutionary tale of lactase persistence in humans. Nat Rev Genet. 2024 Jan; 25(1):7.
PMID: 37749209
Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue.
Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue. Cell Rep. 2024 01 23; 43(1):113616.
PMID: 38150367
DNA methylation-environment interactions in the human genome.
DNA methylation-environment interactions in the human genome. bioRxiv. 2023 Dec 15.
PMID: 37293015
Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species.
Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species. medRxiv. 2023 Nov 30.
PMID: 38076828
BCG vaccination impacts the epigenetic landscape of progenitor cells in human bone marrow.
BCG vaccination impacts the epigenetic landscape of progenitor cells in human bone marrow. bioRxiv. 2023 Nov 28.
PMID: 38077046