John Alverdy, MD, has run a continuously funded NIH-funded laboratory that studies the molecular interactions of bacteria and the intestinal mucosa in order to understand how life-threatening infections arise after trauma and major surgery and during critical illness. He has developed several anti-infective polymer-based compounds that can attenuate the virulence of several multi-drug resistant pathogens that cause life threatening infections in surgical patients and works with the IME to synthesize, refine, and scale the compounds for pre-clinical testing.
The Alverdy lab seeks to better understand the regulation of virulence expression among potential pathogens through investigating the characteristics of the microbial context, molecular machinery that senses that context, and ultimately the lethal combinations of virulence expression that leads to disease. The majority of our work has focused on the sense and response virulence mechanisms of Pseudomonas aeruginosa, a well characterized and clinically important pathogen. We have shown a remarkable potential for this organisms to respond to host environmental cues related to stress, ischemia, immune activation and nutrient depletion. With this core model of environmental regulation of virulence expression, we are pursuing applications in intestinal transplantation, anastomotic and radiation physiology, necrotizing enterocolitis and ischemia/reperfusion injury. We are also investigating similar sense and response mechanisms in other clinically important organisms, including Staphylococcus aureus and Candida albicans. Finally, we are interested in developing virulence-based therapies to prevent virulence activation through modifications in microenvironment of the stressed host such as phosphate repletion and polymer-mediated mucosal replacement therapies.
The ultimate goal of understanding microbial virulence is to provide clinical tools to improve the care of patients. However the complexity of the host-pathogen interaction and the vast amounts of mechanistic information available constitutes a formidable barrier to translational research. Computational agent based modeling is a well suited to dynamically represent mechanistic detail in a modifiable context to recapitulate cellular behavior at the tissue, organ and patient levels.
Michael Reese Hospital and Medical Center
Chicago, IL
Residency in Surgery
1985
University of California
San Francisco
Trauma & Burn Fellowship
1983
Loyola University, Stritch School of Medicine
Chicago, IL
(5th Pathway)
1980
Autonomous University
Guadalajara
MD
1979
Marquette University
Wisconsin
BA
1975
The Combined Effect of Western Diet Consumption and Diclofenac Administration Alters the Gut Microbiota and Promotes Anastomotic Leakage in the Distal Colon.
The Combined Effect of Western Diet Consumption and Diclofenac Administration Alters the Gut Microbiota and Promotes Anastomotic Leakage in the Distal Colon. Biomedicines. 2024 Sep 24; 12(10).
PMID: 39457483
Bowel cleansing, dysbiosis, and postoperative infection: the dots are starting to connect.
Bowel cleansing, dysbiosis, and postoperative infection: the dots are starting to connect. Br J Surg. 2024 Aug 30; 111(9).
PMID: 39222390
Preventing Surgical Site Infections in the Era of Escalating Antibiotic Resistance and Antibiotic Stewardship.
Preventing Surgical Site Infections in the Era of Escalating Antibiotic Resistance and Antibiotic Stewardship. JAMA Surg. 2024 Aug 01; 159(8):949-956.
PMID: 38922606
Invited Commentary: Neurocognitive Testing, Retirement, and Self-Awareness: It Is Just Another Judgment Call.
Invited Commentary: Neurocognitive Testing, Retirement, and Self-Awareness: It Is Just Another Judgment Call. J Am Coll Surg. 2024 Aug 01; 239(2):199-200.
PMID: 38591785
Where do the pathogens that cause surgical site infections come from?
Where do the pathogens that cause surgical site infections come from? Sci Transl Med. 2024 Apr 10; 16(742):eado1449.
PMID: 38598617
Social determinants of health, the microbiome, and surgical injury.
Social determinants of health, the microbiome, and surgical injury. J Trauma Acute Care Surg. 2024 Jul 01; 97(1):158-163.
PMID: 38441071
Comment on: Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries.
Comment on: Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries. Br J Surg. 2024 Mar 02; 111(3).
PMID: 38507424
IDEAL Phase 2a Results: Posterior Rectus Sheath Flap for Hiatal Augmentation in Complex Paraesophageal Hernias.
IDEAL Phase 2a Results: Posterior Rectus Sheath Flap for Hiatal Augmentation in Complex Paraesophageal Hernias. Ann Surg. 2024 Jun 01; 279(6):1000-1007.
PMID: 38375674
Commentary on: Role of Microbiome in the Outcomes Following Surgical Repair of Perianal Fistula: Prospective Cohort Study Design and Preliminary Results.
Commentary on: Role of Microbiome in the Outcomes Following Surgical Repair of Perianal Fistula: Prospective Cohort Study Design and Preliminary Results. World J Surg. 2023 12; 47(12):3380-3381.
PMID: 37930384
Invited Commentary: Scientific Rationale behind Intestinal Alkaline Phosphatase Administration to Enhance Recovery after Pancreaticoduodenectomy.
Invited Commentary: Scientific Rationale behind Intestinal Alkaline Phosphatase Administration to Enhance Recovery after Pancreaticoduodenectomy. J Am Coll Surg. 2024 01 01; 238(1):80-81.
PMID: 37870226