Jeffrey Hubbell

Barry L. Maclean Professor
Biosciences Graduate Program Association
  1. Certelli A, Valente P, Uccelli A, Grosso A, Di Maggio N, D'Amico R, Briquez PS, Hubbell JA, Wolff T, Gürke L, Mujagic E, Gianni-Barrera R, Banfi A. Robust Angiogenesis and Arteriogenesis in the Skin of Diabetic Mice by Transient Delivery of Engineered VEGF and PDGF-BB Proteins in Fibrin Hydrogels. Front Bioeng Biotechnol. 2021; 9:688467. View in: PubMed

  2. Mansurov A, Lauterbach A, Budina E, Alpar AT, Hubbell JA, Ishihara J. Immunoengineering approaches for cytokine therapy. Am J Physiol Cell Physiol. 2021 Jul 07. View in: PubMed

  3. Briquez PS, Tsai HM, Watkins EA, Hubbell JA. Engineered bridge protein with dual affinity for bone morphogenetic protein-2 and collagen enhances bone regeneration for spinal fusion. Sci Adv. 2021 Jun; 7(24). View in: PubMed

  4. Volpatti LR, Wallace RP, Cao S, Raczy MM, Wang R, Gray LT, Alpar AT, Briquez PS, Mitrousis N, Marchell TM, Sasso MS, Nguyen M, Mansurov A, Budina E, Solanki A, Watkins EA, Schnorenberg MR, Tremain AC, Reda JW, Nicolaescu V, Furlong K, Dvorkin S, Yu SS, Manicassamy B, LaBelle JL, Tirrell MV, Randall G, Kwissa M, Swartz MA, Hubbell JA. Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity. bioRxiv. 2021 Apr 08. View in: PubMed

  5. Sasso MS, Mitrousis N, Wang Y, Briquez PS, Hauert S, Ishihara J, Hubbell JA, Swartz MA. Lymphangiogenesis-inducing vaccines elicit potent and long-lasting T cell immunity against melanomas. Sci Adv. 2021 Mar; 7(13). View in: PubMed

  6. Damo M, Wilson DS, Watkins EA, Hubbell JA. Soluble N-Acetylgalactosamine-Modified Antigens Enhance Hepatocyte-Dependent Antigen Cross-Presentation and Result in Antigen-Specific CD8+ T Cell Tolerance Development. Front Immunol. 2021; 12:555095. View in: PubMed

  7. Watkins EA, Antane JT, Roberts JL, Lorentz KM, Zuerndorfer S, Dunaif AC, Bailey LJ, Tremain AC, Nguyen M, De Loera RC, Wallace RP, Weathered RK, Kontos S, Hubbell JA. Persistent antigen exposure via the eryptotic pathway drives terminal T cell dysfunction. Sci Immunol. 2021 Feb 26; 6(56). View in: PubMed

  8. Brubaker CE, Panagiotou V, Demurtas D, Bonner DK, Swartz MA, Hubbell JA. A Cationic Micelle Complex Improves CD8+ T Cell Responses in Vaccination Against Unmodified Protein Antigen. ACS Biomater Sci Eng. 2016 Feb 08; 2(2):231-240. View in: PubMed

  9. Yuba E, Budina E, Katsumata K, Ishihara A, Mansurov A, Alpar AT, Watkins EA, Hosseinchi P, Reda JW, Lauterbach AL, Nguyen M, Solanki A, Kageyama T, Swartz MA, Ishihara J, Hubbell JA. Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin-10 in Murine Models. Arthritis Rheumatol. 2021 05; 73(5):769-778. View in: PubMed

  10. Ishihara A, Ishihara J, Watkins EA, Tremain AC, Nguyen M, Solanki A, Katsumata K, Mansurov A, Budina E, Alpar AT, Hosseinchi P, Maillat L, Reda JW, Kageyama T, Swartz MA, Yuba E, Hubbell JA. Publisher Correction: Prolonged residence of an albumin-IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis. Nat Biomed Eng. 2020 Nov; 4(11):1117. View in: PubMed

  11. Ishihara A, Ishihara J, Watkins EA, Tremain AC, Nguyen M, Solanki A, Katsumata K, Mansurov A, Budina E, Alpar AT, Hosseinchi P, Maillat L, Reda JW, Kageyama T, Swartz MA, Yuba E, Hubbell JA. Prolonged residence of an albumin-IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis. Nat Biomed Eng. 2021 05; 5(5):387-398. View in: PubMed

  12. Missirlis D, Hubbell JA, Tirelli N. Thermally-induced glass formation from hydrogel nanoparticles. Soft Matter. 2006 Nov 15; 2(12):1067-1075. View in: PubMed

  13. Romero P, Donda A, Hubbell JA. An optimized antigen-protein fusion. Nat Biomed Eng. 2020 06; 4(6):583-584. View in: PubMed

  14. Mansurov A, Ishihara J, Hosseinchi P, Potin L, Marchell TM, Ishihara A, Williford JM, Alpar AT, Raczy MM, Gray LT, Swartz MA, Hubbell JA. Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours. Nat Biomed Eng. 2020 05; 4(5):531-543. View in: PubMed

  15. Briquez PS, Hauert S, de Titta A, Gray LT, Alpar AT, Swartz MA, Hubbell JA. Engineering Targeting Materials for Therapeutic Cancer Vaccines. Front Bioeng Biotechnol. 2020; 8:19. View in: PubMed

  16. Katsumata K, Ishihara J, Fukunaga K, Ishihara A, Yuba E, Budina E, Hubbell JA. Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-a antibody in a murine model of rheumatoid arthritis. Arthritis Res Ther. 2019 12 23; 21(1):298. View in: PubMed

  17. Williford JM, Ishihara J, Ishihara A, Mansurov A, Hosseinchi P, Marchell TM, Potin L, Swartz MA, Hubbell JA. Recruitment of CD103+ dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy. Sci Adv. 2019 12; 5(12):eaay1357. View in: PubMed

  18. Katsumata K, Ishihara J, Mansurov A, Ishihara A, Raczy MM, Yuba E, Hubbell JA. Targeting inflammatory sites through collagen affinity enhances the therapeutic efficacy of anti-inflammatory antibodies. Sci Adv. 2019 11; 5(11):eaay1971. View in: PubMed

  19. Mochizuki M, Güç E, Park AJ, Julier Z, Briquez PS, Kuhn GA, Müller R, Swartz MA, Hubbell JA, Martino MM. Growth factors with enhanced syndecan binding generate tonic signalling and promote tissue healing. Nat Biomed Eng. 2020 04; 4(4):463-475. View in: PubMed

  20. Licht C, Rose JC, Anarkoli AO, Blondel D, Roccio M, Haraszti T, Gehlen DB, Hubbell JA, Lutolf MP, De Laporte L. Synthetic 3D PEG-Anisogel Tailored with Fibronectin Fragments Induce Aligned Nerve Extension. Biomacromolecules. 2019 11 11; 20(11):4075-4087. View in: PubMed

  21. Sasaki K, Ishihara J, Ishihara A, Miura R, Mansurov A, Fukunaga K, Hubbell JA. Engineered collagen-binding serum albumin as a drug conjugate carrier for cancer therapy. Sci Adv. 2019 08; 5(8):eaaw6081. View in: PubMed

  22. Wilson DS, Damo M, Hirosue S, Raczy MM, Brünggel K, Diaceri G, Quaglia-Thermes X, Hubbell JA. Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes. Nat Biomed Eng. 2019 10; 3(10):817-829. View in: PubMed

  23. Ishihara J, Ishihara A, Starke RD, Peghaire CR, Smith KE, McKinnon TAJ, Tabata Y, Sasaki K, White MJV, Fukunaga K, Laffan MA, Lutolf MP, Randi AM, Hubbell JA. The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing. Blood. 2019 06 13; 133(24):2559-2569. View in: PubMed

  24. Ishihara J, Ishihara A, Sasaki K, Lee SS, Williford JM, Yasui M, Abe H, Potin L, Hosseinchi P, Fukunaga K, Raczy MM, Gray LT, Mansurov A, Katsumata K, Fukayama M, Kron SJ, Swartz MA, Hubbell JA. Targeted antibody and cytokine cancer immunotherapies through collagen affinity. Sci Transl Med. 2019 04 10; 11(487). View in: PubMed

  25. Lih E, Park W, Park KW, Chun SY, Kim H, Joung YK, Kwon TG, Hubbell JA, Han DK. A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration. ACS Cent Sci. 2019 Mar 27; 5(3):458-467. View in: PubMed

  26. Vardar E, Vythilingam G, Pinnagoda K, Engelhardt EM, Zambelli PY, Hubbell JA, Lutolf MP, Frey P, Larsson HM. A bioactive injectable bulking material; a potential therapeutic approach for stress urinary incontinence. Biomaterials. 2019 06; 206:41-48. View in: PubMed

  27. Botelho NK, Tschumi BO, Hubbell JA, Swartz MA, Donda A, Romero P. Combination of Synthetic Long Peptides and XCL1 Fusion Proteins Results in Superior Tumor Control. Front Immunol. 2019; 10:294. View in: PubMed

  28. Zielinski MS, Vardar E, Vythilingam G, Engelhardt EM, Hubbell JA, Frey P, Larsson HM. Quantitative intrinsic auto-cathodoluminescence can resolve spectral signatures of tissue-isolated collagen extracellular matrix. Commun Biol. 2019; 2:69. View in: PubMed

  29. Hubbell JA, Swartz MA. Trojan horses for immunotherapy. Nat Nanotechnol. 2019 03; 14(3):196-197. View in: PubMed

  30. Wilson DS, Hirosue S, Raczy MM, Bonilla-Ramirez L, Jeanbart L, Wang R, Kwissa M, Franetich JF, Broggi MAS, Diaceri G, Quaglia-Thermes X, Mazier D, Swartz MA, Hubbell JA. Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity. Nat Mater. 2019 02; 18(2):175-185. View in: PubMed

  31. Ishihara J, Ishihara A, Potin L, Hosseinchi P, Fukunaga K, Damo M, Gajewski TF, Swartz MA, Hubbell JA. Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity. . 2018 11; 17(11):2399-2411. View in: PubMed

  32. Larsson HM, Vythilingam G, Pinnagoda K, Vardar E, Engelhardt EM, Sothilingam S, Thambidorai RC, Kamarul T, Hubbell JA, Frey P. Fiber density of collagen grafts impacts rabbit urethral regeneration. Sci Rep. 2018 07 03; 8(1):10057. View in: PubMed

  33. Ishihara J, Ishihara A, Fukunaga K, Sasaki K, White MJV, Briquez PS, Hubbell JA. Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing. Nat Commun. 2018 06 04; 9(1):2163. View in: PubMed

  34. Lih E, Kum CH, Park W, Chun SY, Cho Y, Joung YK, Park KS, Hong YJ, Ahn DJ, Kim BS, Kwon TG, Jeong MH, Hubbell JA, Han DK. Modified Magnesium Hydroxide Nanoparticles Inhibit the Inflammatory Response to Biodegradable Poly(lactide- co-glycolide) Implants. ACS Nano. 2018 07 24; 12(7):6917-6925. View in: PubMed

  35. Guo AZ, Sevgen E, Sidky H, Whitmer JK, Hubbell JA, de Pablo JJ. Adaptive enhanced sampling by force-biasing using neural networks. J Chem Phys. 2018 Apr 07; 148(13):134108. View in: PubMed

  36. Vardar E, Larsson HM, Allazetta S, Engelhardt EM, Pinnagoda K, Vythilingam G, Hubbell JA, Lutolf MP, Frey P. Microfluidic production of bioactive fibrin micro-beads embedded in crosslinked collagen used as an injectable bulking agent for urinary incontinence treatment. Acta Biomater. 2018 02; 67:156-166. View in: PubMed

  37. Ishihara J, Fukunaga K, Ishihara A, Larsson HM, Potin L, Hosseinchi P, Galliverti G, Swartz MA, Hubbell JA. Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events. Sci Transl Med. 2017 Nov 08; 9(415). View in: PubMed

  38. Manzoli V, Villa C, Bayer AL, Morales LC, Molano RD, Torrente Y, Ricordi C, Hubbell JA, Tomei AA. Immunoisolation of murine islet allografts in vascularized sites through conformal coating with polyethylene glycol. Am J Transplant. 2018 03; 18(3):590-603. View in: PubMed

  39. Galan-Navarro C, Rincon-Restrepo M, Zimmer G, Ollmann Saphire E, Hubbell JA, Hirosue S, Swartz MA, Kunz S. Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein. Virology. 2017 12; 512:161-171. View in: PubMed

  40. Baekkeskov S, Hubbell JA, Phelps EA. Bioengineering strategies for inducing tolerance in autoimmune diabetes. Adv Drug Deliv Rev. 2017 05 15; 114:256-265. View in: PubMed

  41. Phelps EA, Cianciaruso C, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S. Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation. Sci Rep. 2017 05 09; 7:46801. View in: PubMed

  42. Briquez PS, Lorentz KM, Larsson HM, Frey P, Hubbell JA. Human Kunitz-type protease inhibitor engineered for enhanced matrix retention extends longevity of fibrin biomaterials. Biomaterials. 2017 Aug; 135:1-9. View in: PubMed

  43. Güç E, Briquez PS, Foretay D, Fankhauser MA, Hubbell JA, Kilarski WW, Swartz MA. Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling. Biomaterials. 2017 07; 131:160-175. View in: PubMed

  44. Rincon-Restrepo M, Mayer A, Hauert S, Bonner DK, Phelps EA, Hubbell JA, Swartz MA, Hirosue S. Vaccine nanocarriers: Coupling intracellular pathways and cellular biodistribution to control CD4 vs CD8 T cell responses. Biomaterials. 2017 07; 132:48-58. View in: PubMed

  45. Phelps EA, Cianciaruso C, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S. Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation. Sci Rep. 2017 04 12; 7:45961. View in: PubMed

  46. Dowling DJ, Scott EA, Scheid A, Bergelson I, Joshi S, Pietrasanta C, Brightman S, Sanchez-Schmitz G, Van Haren SD, Ninkovic J, Kats D, Guiducci C, de Titta A, Bonner DK, Hirosue S, Swartz MA, Hubbell JA, Levy O. Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses. J Allergy Clin Immunol. 2017 Nov; 140(5):1339-1350. View in: PubMed

  47. Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA. (Re)Building a Kidney. J Am Soc Nephrol. 2017 May; 28(5):1370-1378. View in: PubMed

  48. Cianciaruso C, Phelps EA, Pasquier M, Hamelin R, Demurtas D, Alibashe Ahmed M, Piemonti L, Hirosue S, Swartz MA, De Palma M, Hubbell JA, Baekkeskov S. Primary Human and Rat ß-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity. Diabetes. 2017 02; 66(2):460-473. View in: PubMed

  49. Lee M, Ahn JI, Ahn JY, Yang WS, Hubbell JA, Lim JM, Lee ST. Difference in suitable mechanical properties of three-dimensional, synthetic scaffolds for self-renewing mouse embryonic stem cells of different genetic backgrounds. . 2017 Nov; 105(8):2261-2268. View in: PubMed

  50. Pinnagoda K, Larsson HM, Vythilingam G, Vardar E, Engelhardt EM, Thambidorai RC, Hubbell JA, Frey P. Engineered acellular collagen scaffold for endogenous cell guidance, a novel approach in urethral regeneration. Acta Biomater. 2016 10 01; 43:208-217. View in: PubMed

  51. Vardar E, Larsson HM, Engelhardt EM, Pinnagoda K, Briquez PS, Hubbell JA, Frey P. IGF-1-containing multi-layered collagen-fibrin hybrid scaffolds for bladder tissue engineering. Acta Biomater. 2016 09 01; 41:75-85. View in: PubMed

  52. Phelps EA, Cianciaruso C, Michael IP, Pasquier M, Kanaani J, Nano R, Lavallard V, Billestrup N, Hubbell JA, Baekkeskov S. Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity. Diabetes. 2016 09; 65(9):2686-99. View in: PubMed

  53. Julier Z, de Titta A, Grimm AJ, Simeoni E, Swartz MA, Hubbell JA. Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses. Vaccine. 2016 05 05; 34(21):2453-2459. View in: PubMed

  54. Zielinski MS, Choi JW, La Grange T, Modestino M, Hashemi SM, Pu Y, Birkhold S, Hubbell JA, Psaltis D. Hollow Mesoporous Plasmonic Nanoshells for Enhanced Solar Vapor Generation. . 2016 Apr 13; 16(4):2159-67. View in: PubMed

  55. Damo M, Wilson DS, Simeoni E, Hubbell JA. TLR-3 stimulation improves anti-tumor immunity elicited by dendritic cell exosome-based vaccines in a murine model of melanoma. Sci Rep. 2015 Dec 03; 5:17622. View in: PubMed

  56. Lorentz KM, Kontos S, Diaceri G, Henry H, Hubbell JA. Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase. Sci Adv. 2015 Jul; 1(6):e1500112. View in: PubMed

  57. Mitchell AC, Briquez PS, Hubbell JA, Cochran JR. Engineering growth factors for regenerative medicine applications. Acta Biomater. 2016 Jan; 30:1-12. View in: PubMed

  58. Grimm AJ, Kontos S, Diaceri G, Quaglia-Thermes X, Hubbell JA. Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens. Sci Rep. 2015 Oct 29; 5:15907. View in: PubMed

  59. Husseinil GA, Kherbeckl L, Pitt WG, Hubbell JA, Christensen DA, Velluto D. Kinetics of Ultrasonic Drug Delivery from Targeted Micelles. J Nanosci Nanotechnol. 2015 Mar; 15(3):2099-104. View in: PubMed

  60. Ballester M, Jeanbart L, de Titta A, Nembrini C, Marsland BJ, Hubbell JA, Swartz MA. Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice. Sci Rep. 2015 Sep 21; 5:14274. View in: PubMed

  61. Briquez PS, Hubbell JA, Martino MM. Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing. Adv Wound Care (New Rochelle). 2015 Aug 01; 4(8):479-489. View in: PubMed

  62. Kontos S, Grimm AJ, Hubbell JA. Engineering antigen-specific immunological tolerance. Curr Opin Immunol. 2015 Aug; 35:80-8. View in: PubMed

  63. Brubaker CE, Velluto D, Demurtas D, Phelps EA, Hubbell JA. Crystalline Oligo(ethylene sulfide) Domains Define Highly Stable Supramolecular Block Copolymer Assemblies. ACS Nano. 2015 Jul 28; 9(7):6872-81. View in: PubMed

  64. Vardar E, Engelhardt EM, Larsson HM, Mouloungui E, Pinnagoda K, Hubbell JA, Frey P. Tubular Compressed Collagen Scaffolds for Ureteral Tissue Engineering in a Flow Bioreactor System. Tissue Eng Part A. 2015 Sep; 21(17-18):2334-45. View in: PubMed

  65. Hubbell JA. Prescription for a pharmacyte. Sci Transl Med. 2015 Jun 10; 7(291):291fs23. View in: PubMed

  66. Jeanbart L, Kourtis IC, van der Vlies AJ, Swartz MA, Hubbell JA. 6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice. Cancer Immunol Immunother. 2015 Aug; 64(8):1033-46. View in: PubMed

  67. Martino MM, Briquez PS, Maruyama K, Hubbell JA. Extracellular matrix-inspired growth factor delivery systems for bone regeneration. Adv Drug Deliv Rev. 2015 Nov 01; 94:41-52. View in: PubMed

  68. Martino MM, Brkic S, Bovo E, Burger M, Schaefer DJ, Wolff T, Gürke L, Briquez PS, Larsson HM, Gianni-Barrera R, Hubbell JA, Banfi A. Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine. Front Bioeng Biotechnol. 2015; 3:45. View in: PubMed

  69. Najjar M, Manzoli V, Abreu M, Villa C, Martino MM, Molano RD, Torrente Y, Pileggi A, Inverardi L, Ricordi C, Hubbell JA, Tomei AA. Fibrin gels engineered with pro-angiogenic growth factors promote engraftment of pancreatic islets in extrahepatic sites in mice. Biotechnol Bioeng. 2015 Sep; 112(9):1916-26. View in: PubMed

  70. Julier Z, Martino MM, de Titta A, Jeanbart L, Hubbell JA. The TLR4 agonist fibronectin extra domain A is cryptic, exposed by elastase-2; use in a fibrin matrix cancer vaccine. Sci Rep. 2015 Feb 24; 5:8569. View in: PubMed

  71. Ferreira DS, Lin YA, Cui H, Hubbell JA, Reis RL, Azevedo HS. Molecularly engineered self-assembling membranes for cell-mediated degradation. Adv Healthc Mater. 2015 Mar 11; 4(4):602-12. View in: PubMed

  72. Zakrzewski JL, van den Brink MR, Hubbell JA. Overcoming immunological barriers in regenerative medicine. Nat Biotechnol. 2014 Aug; 32(8):786-94. View in: PubMed

  73. Tomei AA, Manzoli V, Fraker CA, Giraldo J, Velluto D, Najjar M, Pileggi A, Molano RD, Ricordi C, Stabler CL, Hubbell JA. Device design and materials optimization of conformal coating for islets of Langerhans. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10514-9. View in: PubMed

  74. Vila OF, Martino MM, Nebuloni L, Kuhn G, Pérez-Amodio S, Müller R, Hubbell JA, Rubio N, Blanco J. Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors. Acta Biomater. 2014 Oct; 10(10):4377-89. View in: PubMed

  75. Jeanbart L, Ballester M, de Titta A, Corthésy P, Romero P, Hubbell JA, Swartz MA. Enhancing efficacy of anticancer vaccines by targeted delivery to tumor-draining lymph nodes. Cancer Immunol Res. 2014 May; 2(5):436-47. View in: PubMed

  76. Sacchi V, Mittermayr R, Hartinger J, Martino MM, Lorentz KM, Wolbank S, Hofmann A, Largo RA, Marschall JS, Groppa E, Gianni-Barrera R, Ehrbar M, Hubbell JA, Redl H, Banfi A. Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):6952-7. View in: PubMed

  77. Larsson HM, Gorostidi F, Hubbell JA, Barrandon Y, Frey P. Clonal, self-renewing and differentiating human and porcine urothelial cells, a novel stem cell population. PLoS One. 2014; 9(2):e90006. View in: PubMed

  78. Martino MM, Briquez PS, Güç E, Tortelli F, Kilarski WW, Metzger S, Rice JJ, Kuhn GA, Müller R, Swartz MA, Hubbell JA. Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing. Science. 2014 Feb 21; 343(6173):885-8. View in: PubMed

  79. Ahn JI, Kim GA, Kwon HS, Ahn JY, Hubbell JA, Song YS, Lee ST, Lim JM. Culture of preantral follicles in poly(ethylene) glycol-based, three-dimensional hydrogel: a relationship between swelling ratio and follicular developments. J Tissue Eng Regen Med. 2015 Mar; 9(3):319-23. View in: PubMed

  80. de Titta A, Ballester M, Julier Z, Nembrini C, Jeanbart L, van der Vlies AJ, Swartz MA, Hubbell JA. Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19902-7. View in: PubMed

  81. Tortelli F, Pisano M, Briquez PS, Martino MM, Hubbell JA. Fibronectin binding modulates CXCL11 activity and facilitates wound healing. PLoS One. 2013; 8(10):e79610. View in: PubMed

  82. Hubbell JA, Langer R. Translating materials design to the clinic. Nat Mater. 2013 Nov; 12(11):963-6. View in: PubMed

  83. Thomas SN, Vokali E, Lund AW, Hubbell JA, Swartz MA. Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response. Biomaterials. 2014 Jan; 35(2):814-24. View in: PubMed

  84. Mosiewicz KA, Kolb L, van der Vlies AJ, Martino MM, Lienemann PS, Hubbell JA, Ehrbar M, Lutolf MP. In situ cell manipulation through enzymatic hydrogel photopatterning. Nat Mater. 2013 Nov; 12(11):1072-8. View in: PubMed

  85. Rutkowski JM, Ihm JE, Lee ST, Kilarski WW, Greenwood VI, Pasquier MC, Quazzola A, Trono D, Hubbell JA, Swartz MA. VEGFR-3 neutralization inhibits ovarian lymphangiogenesis, follicle maturation, and murine pregnancy. Am J Pathol. 2013 Nov; 183(5):1596-1607. View in: PubMed

  86. Lee K, Hubbell JA. Tissue, cell and engineering. Curr Opin Biotechnol. 2013 Oct; 24(5):827-9. View in: PubMed

  87. Hasegawa U, van der Vlies AJ, Wandrey C, Hubbell JA. Preparation of well-defined ibuprofen prodrug micelles by RAFT polymerization. Biomacromolecules. 2013 Sep 09; 14(9):3314-20. View in: PubMed

  88. Brady AC, Martino MM, Pedraza E, Sukert S, Pileggi A, Ricordi C, Hubbell JA, Stabler CL. Proangiogenic hydrogels within macroporous scaffolds enhance islet engraftment in an extrahepatic site. Tissue Eng Part A. 2013 Dec; 19(23-24):2544-52. View in: PubMed

  89. Traub S, Morgner J, Martino MM, Höning S, Swartz MA, Wickström SA, Hubbell JA, Eming SA. The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165. Biomaterials. 2013 Aug; 34(24):5958-68. View in: PubMed

  90. Hoffmann DC, Willenborg S, Koch M, Zwolanek D, Müller S, Becker AK, Metzger S, Ehrbar M, Kurschat P, Hellmich M, Hubbell JA, Eming SA. Proteolytic processing regulates placental growth factor activities. J Biol Chem. 2013 Jun 21; 288(25):17976-89. View in: PubMed

  91. De Laporte L, Rice JJ, Tortelli F, Hubbell JA. Tenascin C promiscuously binds growth factors via its fifth fibronectin type III-like domain. PLoS One. 2013; 8(4):e62076. View in: PubMed

  92. Kourtis IC, Hirosue S, de Titta A, Kontos S, Stegmann T, Hubbell JA, Swartz MA. Peripherally administered nanoparticles target monocytic myeloid cells, secondary lymphoid organs and tumors in mice. PLoS One. 2013; 8(4):e61646. View in: PubMed

  93. Martino MM, Briquez PS, Ranga A, Lutolf MP, Hubbell JA. Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4563-8. View in: PubMed

  94. Stano A, Scott EA, Dane KY, Swartz MA, Hubbell JA. Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles. Biomaterials. 2013 Jun; 34(17):4339-46. View in: PubMed

  95. Garcia-Cordero JL, Nembrini C, Stano A, Hubbell JA, Maerkl SJ. A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening. Integr Biol (Camb). 2013 Apr; 5(4):650-8. View in: PubMed

  96. Jang M, Lee ST, Kim JW, Yang JH, Yoon JK, Park JC, Ryoo HM, van der Vlies AJ, Ahn JY, Hubbell JA, Song YS, Lee G, Lim JM. A feeder-free, defined three-dimensional polyethylene glycol-based extracellular matrix niche for culture of human embryonic stem cells. Biomaterials. 2013 May; 34(14):3571-80. View in: PubMed

  97. Kontos S, Kourtis IC, Dane KY, Hubbell JA. Engineering antigens for in situ erythrocyte binding induces T-cell deletion. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):E60-8. View in: PubMed

  98. Larsson HM, Lee ST, Roccio M, Velluto D, Lutolf MP, Frey P, Hubbell JA. Sorting live stem cells based on Sox2 mRNA expression. PLoS One. 2012; 7(11):e49874. View in: PubMed

  99. Vallée JP, Hauwel M, Lepetit-Coiffé M, Bei W, Montet-Abou K, Meda P, Gardier S, Zammaretti P, Kraehenbuehl TP, Herrmann F, Hubbell JA, Jaconi ME. Embryonic stem cell-based cardiopatches improve cardiac function in infarcted rats. Stem Cells Transl Med. 2012 Mar; 1(3):248-60. View in: PubMed

  100. Rice JJ, Martino MM, De Laporte L, Tortelli F, Briquez PS, Hubbell JA. Engineering the regenerative microenvironment with biomaterials. Adv Healthc Mater. 2013 Jan; 2(1):57-71. View in: PubMed

  101. Stano A, Nembrini C, Swartz MA, Hubbell JA, Simeoni E. Nanoparticle size influences the magnitude and quality of mucosal immune responses after intranasal immunization. Vaccine. 2012 Dec 14; 30(52):7541-6. View in: PubMed

  102. Kisiel M, Martino MM, Ventura M, Hubbell JA, Hilborn J, Ossipov DA. Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment. Biomaterials. 2013 Jan; 34(3):704-12. View in: PubMed

  103. Lee ST, Yun JI, van der Vlies AJ, Kontos S, Jang M, Gong SP, Kim DY, Lim JM, Hubbell JA. Long-term maintenance of mouse embryonic stem cell pluripotency by manipulating integrin signaling within 3D scaffolds without active Stat3. Biomaterials. 2012 Dec; 33(35):8934-42. View in: PubMed

  104. van der Vlies AJ, Hasegawa U, Hubbell JA. Reduction-sensitive tioguanine prodrug micelles. Mol Pharm. 2012 Oct 01; 9(10):2812-8. View in: PubMed

  105. Swartz MA, Hirosue S, Hubbell JA. Engineering approaches to immunotherapy. Sci Transl Med. 2012 Aug 22; 4(148):148rv9. View in: PubMed

  106. Vasdekis AE, Scott EA, O'Neil CP, Psaltis D, Hubbell JA. Precision intracellular delivery based on optofluidic polymersome rupture. ACS Nano. 2012 Sep 25; 6(9):7850-7. View in: PubMed

  107. Hubbell JA, Chilkoti A. Chemistry. Nanomaterials for drug delivery. Science. 2012 Jul 20; 337(6092):303-5. View in: PubMed

  108. Husseini GA, Velluto D, Kherbeck L, Pitt WG, Hubbell JA, Christensen DA. Investigating the acoustic release of doxorubicin from targeted micelles. Colloids Surf B Biointerfaces. 2013 Jan 01; 101:153-5. View in: PubMed

  109. Micol LA, Arenas da Silva LF, Geutjes PJ, Oosterwijk E, Hubbell JA, Feitz WF, Frey P. In-vivo performance of high-density collagen gel tubes for urethral regeneration in a rabbit model. Biomaterials. 2012 Oct; 33(30):7447-55. View in: PubMed

  110. Eby JK, Dane KY, O'Neil CP, Hirosue S, Swartz MA, Hubbell JA. Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization. Acta Biomater. 2012 Sep; 8(9):3210-7. View in: PubMed

  111. Scott EA, Stano A, Gillard M, Maio-Liu AC, Swartz MA, Hubbell JA. Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes. Biomaterials. 2012 Sep; 33(26):6211-9. View in: PubMed

  112. Yu SS, Lau CM, Thomas SN, Jerome WG, Maron DJ, Dickerson JH, Hubbell JA, Giorgio TD. Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages. Int J Nanomedicine. 2012; 7:799-813. View in: PubMed

  113. Kontos S, Hubbell JA. Drug development: longer-lived proteins. Chem Soc Rev. 2012 Apr 07; 41(7):2686-95. View in: PubMed

  114. Friedl P, Hubbell J, Livingston D, Mihich E. Twenty-third annual Pezcoller Symposium: engineering influences in cancer research. Cancer Res. 2012 Feb 15; 72(4):841-4. View in: PubMed

  115. Lorentz KM, Yang L, Frey P, Hubbell JA. Engineered insulin-like growth factor-1 for improved smooth muscle regeneration. Biomaterials. 2012 Jan; 33(2):494-503. View in: PubMed

  116. Nembrini C, Stano A, Dane KY, Ballester M, van der Vlies AJ, Marsland BJ, Swartz MA, Hubbell JA. Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):E989-97. View in: PubMed

  117. Velluto D, Thomas SN, Simeoni E, Swartz MA, Hubbell JA. PEG-b-PPS-b-PEI micelles and PEG-b-PPS/PEG-b-PPS-b-PEI mixed micelles as non-viral vectors for plasmid DNA: tumor immunotoxicity in B16F10 melanoma. Biomaterials. 2011 Dec; 32(36):9839-47. View in: PubMed

  118. Martino MM, Tortelli F, Mochizuki M, Traub S, Ben-David D, Kuhn GA, Müller R, Livne E, Eming SA, Hubbell JA. Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing. Sci Transl Med. 2011 Sep 14; 3(100):100ra89. View in: PubMed

  119. Veneziale RW, Kishnani NS, Nelson J, Resendez JC, Frank DW, Cai XY, Xie L, Cullen C, Frugone CA, Rosenfeld C, Hubbell J, Maxwell SE, Sugarman BJ, Hutchins B, Maneval D, Treinen KA. Toxicity and exposure of an adenovirus containing human interferon alpha-2b following intracystic administration in cynomolgus monkeys. Gene Ther. 2012 Jul; 19(7):742-51. View in: PubMed

  120. Dane KY, Nembrini C, Tomei AA, Eby JK, O'Neil CP, Velluto D, Swartz MA, Inverardi L, Hubbell JA. Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival. J Control Release. 2011 Dec 10; 156(2):154-60. View in: PubMed

  121. Ballester M, Nembrini C, Dhar N, de Titta A, de Piano C, Pasquier M, Simeoni E, van der Vlies AJ, McKinney JD, Hubbell JA, Swartz MA. Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis. Vaccine. 2011 Sep 16; 29(40):6959-66. View in: PubMed

  122. Eming SA, Hubbell JA. Extracellular matrix in angiogenesis: dynamic structures with translational potential. Exp Dermatol. 2011 Jul; 20(7):605-13. View in: PubMed

  123. Engelhardt EM, Micol LA, Houis S, Wurm FM, Hilborn J, Hubbell JA, Frey P. A collagen-poly(lactic acid-co-?-caprolactone) hybrid scaffold for bladder tissue regeneration. Biomaterials. 2011 Jun; 32(16):3969-76. View in: PubMed

  124. Sawhney AS, Hubbell JA. In situ photopolymerized hydrogels for vascular and peritoneal wound healing. Methods Mol Med. 1999; 18:85-100. View in: PubMed

  125. Yu SS, Scherer RL, Ortega RA, Bell CS, O'Neil CP, Hubbell JA, Giorgio TD. Enzymatic- and temperature-sensitive controlled release of ultrasmall superparamagnetic iron oxides (USPIOs). J Nanobiotechnology. 2011 Feb 27; 9:7. View in: PubMed

  126. Thomas SN, van der Vlies AJ, O'Neil CP, Reddy ST, Yu SS, Giorgio TD, Swartz MA, Hubbell JA. Engineering complement activation on polypropylene sulfide vaccine nanoparticles. Biomaterials. 2011 Mar; 32(8):2194-203. View in: PubMed

  127. Di Crescenzo A, Velluto D, Hubbell JA, Fontana A. Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs. Nanoscale. 2011 Mar; 3(3):925-8. View in: PubMed

  128. Wandrey C, Hasegawa U, van der Vlies AJ, O'Neil C, Angelova N, Hubbell JA. Analytical ultracentrifugation to support the development of biomaterials and biomedical devices. Methods. 2011 May; 54(1):92-100. View in: PubMed

  129. Hasegawa U, van der Vlies AJ, Simeoni E, Wandrey C, Hubbell JA. Carbon monoxide-releasing micelles for immunotherapy. J Am Chem Soc. 2010 Dec 29; 132(51):18273-80. View in: PubMed

  130. Stano A, van der Vlies AJ, Martino MM, Swartz MA, Hubbell JA, Simeoni E. PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration. Vaccine. 2011 Jan 17; 29(4):804-12. View in: PubMed

  131. Micol LA, Ananta M, Engelhardt EM, Mudera VC, Brown RA, Hubbell JA, Frey P. High-density collagen gel tubes as a matrix for primary human bladder smooth muscle cells. Biomaterials. 2011 Feb; 32(6):1543-8. View in: PubMed

  132. Patterson J, Hubbell JA. SPARC-derived protease substrates to enhance the plasmin sensitivity of molecularly engineered PEG hydrogels. Biomaterials. 2011 Feb; 32(5):1301-10. View in: PubMed

  133. Kraehenbuehl TP, Ferreira LS, Hayward AM, Nahrendorf M, van der Vlies AJ, Vasile E, Weissleder R, Langer R, Hubbell JA. Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction. Biomaterials. 2011 Feb; 32(4):1102-9. View in: PubMed

  134. Hubbell JA. Drug development: Longer-lived proteins. Nature. 2010 Oct 28; 467(7319):1051-2. View in: PubMed

  135. Hirosue S, Kourtis IC, van der Vlies AJ, Hubbell JA, Swartz MA. Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation. Vaccine. 2010 Nov 23; 28(50):7897-906. View in: PubMed

  136. Lorentz KM, Kontos S, Frey P, Hubbell JA. Engineered aprotinin for improved stability of fibrin biomaterials. Biomaterials. 2011 Jan; 32(2):430-8. View in: PubMed

  137. Kontos S, Hubbell JA. Improving protein pharmacokinetics by engineering erythrocyte affinity. Mol Pharm. 2010 Dec 06; 7(6):2141-7. View in: PubMed

  138. Popa AM, Angeloni S, Bürgi T, Hubbell JA, Heinzelmann H, Pugin R. Dynamic perspective on the function of thermoresponsive nanopores from in situ AFM and ATR-IR investigations. Langmuir. 2010 Oct 05; 26(19):15356-65. View in: PubMed

  139. Bott K, Upton Z, Schrobback K, Ehrbar M, Hubbell JA, Lutolf MP, Rizzi SC. The effect of matrix characteristics on fibroblast proliferation in 3D gels. Biomaterials. 2010 Nov; 31(32):8454-64. View in: PubMed

  140. Martino MM, Hubbell JA. The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. FASEB J. 2010 Dec; 24(12):4711-21. View in: PubMed

  141. Patterson J, Hubbell JA. Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. Biomaterials. 2010 Oct; 31(30):7836-45. View in: PubMed

  142. Mercanzini A, Reddy ST, Velluto D, Colin P, Maillard A, Bensadoun JC, Hubbell JA, Renaud P. Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses. J Control Release. 2010 Aug 03; 145(3):196-202. View in: PubMed

  143. van der Vlies AJ, O'Neil CP, Hasegawa U, Hammond N, Hubbell JA. Synthesis of pyridyl disulfide-functionalized nanoparticles for conjugating thiol-containing small molecules, peptides, and proteins. Bioconjug Chem. 2010 Apr 21; 21(4):653-62. View in: PubMed

  144. Ramseyer P, Micol LA, Engelhardt EM, Osterheld MC, Hubbell JA, Frey P. In vivo study of an injectable poly(acrylonitrile)-based hydrogel paste as a bulking agent for the treatment of urinary incontinence. Biomaterials. 2010 Jun; 31(17):4613-9. View in: PubMed

  145. Vasdekis AE, O'Neil CP, Hubbell JA, Psaltis D. Microfluidic assays for DNA manipulation based on a block copolymer immobilization strategy. Biomacromolecules. 2010 Mar 08; 11(3):827-31. View in: PubMed

  146. Rothenfluh DA, Hubbell JA. Integration column: biofunctional polymeric nanoparticles for spatio-temporal control of drug delivery and biomedical applications. Integr Biol (Camb). 2009 Jul; 1(7):446-51. View in: PubMed

  147. Missirlis D, Hubbell JA. In vitro uptake of amphiphilic, hydrogel nanoparticles by J774A.1 cells. J Biomed Mater Res A. 2010 Jun 15; 93(4):1557-65. View in: PubMed

  148. Hubbell JA, Thomas SN, Swartz MA. Materials engineering for immunomodulation. Nature. 2009 Nov 26; 462(7272):449-60. View in: PubMed

  149. Lee ST, Yun JI, Jo YS, Mochizuki M, van der Vlies AJ, Kontos S, Ihm JE, Lim JM, Hubbell JA. Engineering integrin signaling for promoting embryonic stem cell self-renewal in a precisely defined niche. Biomaterials. 2010 Feb; 31(6):1219-26. View in: PubMed

  150. Lavanant L, Pullin B, Hubbell JA, Klok HA. A facile strategy for the modification of polyethylene substrates with non-fouling, bioactive poly(poly(ethylene glycol) methacrylate) brushes. Macromol Biosci. 2010 Jan 11; 10(1):101-8. View in: PubMed

  151. Popa AM, Niedermann P, Heinzelmann H, Hubbell JA, Pugin R. Fabrication of nanopore arrays and ultrathin silicon nitride membranes by block-copolymer-assisted lithography. Nanotechnology. 2009 Dec 02; 20(48):485303. View in: PubMed

  152. Engelhardt EM, Stegberg E, Brown RA, Hubbell JA, Wurm FM, Adam M, Frey P. Compressed collagen gel: a novel scaffold for human bladder cells. J Tissue Eng Regen Med. 2010 Feb; 4(2):123-30. View in: PubMed

  153. Jo YS, van der Vlies AJ, Gantz J, Thacher TN, Antonijevic S, Cavadini S, Demurtas D, Stergiopulos N, Hubbell JA. Micelles for delivery of nitric oxide. J Am Chem Soc. 2009 Oct 14; 131(40):14413-8. View in: PubMed

  154. Cerritelli S, O'Neil CP, Velluto D, Fontana A, Adrian M, Dubochet J, Hubbell JA. Aggregation behavior of poly(ethylene glycol-bl-propylene sulfide) di- and triblock copolymers in aqueous solution. Langmuir. 2009 Oct 06; 25(19):11328-35. View in: PubMed

  155. Jo YS, Rizzi SC, Ehrbar M, Weber FE, Hubbell JA, Lutolf MP. Biomimetic PEG hydrogels crosslinked with minimal plasmin-sensitive tri-amino acid peptides. J Biomed Mater Res A. 2010 Jun 01; 93(3):870-7. View in: PubMed

  156. O'Neil CP, Suzuki T, Demurtas D, Finka A, Hubbell JA. A novel method for the encapsulation of biomolecules into polymersomes via direct hydration. Langmuir. 2009 Aug 18; 25(16):9025-9. View in: PubMed


  158. Kraehenbuehl TP, Ferreira LS, Zammaretti P, Hubbell JA, Langer R. Cell-responsive hydrogel for encapsulation of vascular cells. Biomaterials. 2009 Sep; 30(26):4318-24. View in: PubMed

  159. Bearinger JP, Stone G, Dugan LC, El Dasher B, Stockton C, Conway JW, Kuenzler T, Hubbell JA. Porphyrin-based photocatalytic nanolithography: a new fabrication tool for protein arrays. Mol Cell Proteomics. 2009 Aug; 8(8):1823-31. View in: PubMed

  160. O'Neil CP, van der Vlies AJ, Velluto D, Wandrey C, Demurtas D, Dubochet J, Hubbell JA. Extracellular matrix binding mixed micelles for drug delivery applications. J Control Release. 2009 Jul 20; 137(2):146-51. View in: PubMed

  161. Bearinger J, Dugan L, Wu L, Hill H, Christian A, Hubbell J. Chemical tethering of motile bacteria to silicon surfaces. Biotechniques. 2009 Mar; 46(3):209-16. View in: PubMed

  162. Arrighi I, Mark S, Alvisi M, von Rechenberg B, Hubbell JA, Schense JC. Bone healing induced by local delivery of an engineered parathyroid hormone prodrug. Biomaterials. 2009 Mar; 30(9):1763-71. View in: PubMed

  163. Bearinger JP, Stone G, Hiddessen AL, Dugan LC, Wu L, Hailey P, Conway JW, Kuenzler T, Feller L, Cerritelli S, Hubbell JA. Phototocatalytic lithography of poly(propylene sulfide) block copolymers: toward high-throughput nanolithography for biomolecular arraying applications. Langmuir. 2009 Jan 20; 25(2):1238-44. View in: PubMed

  164. Martino MM, Mochizuki M, Rothenfluh DA, Rempel SA, Hubbell JA, Barker TH. Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability. Biomaterials. 2009 Feb; 30(6):1089-97. View in: PubMed

  165. Salaklang J, Steitz B, Finka A, O'Neil CP, Moniatte M, van der Vlies AJ, Giorgio TD, Hofmann H, Hubbell JA, Petri-Fink A. Superparamagnetic nanoparticles as a powerful systems biology characterization tool in the physiological context. Angew Chem Int Ed Engl. 2008; 47(41):7857-60. View in: PubMed

  166. Hubbell JA. Cellular matrices: Physiology in microfluidics. Nat Mater. 2008 Aug; 7(8):609-10. View in: PubMed

  167. Herbert CB, Hernandez AM, Hubbell JA. Platelet adhesion to polyurethane blended with polytetramethylene oxide. Biotechnol Bioeng. 1996 Oct 05; 52(1):81-8. View in: PubMed

  168. Sawhney AS, Pathak CP, Hubbell JA. Modification of islet of langerhans surfaces with immunoprotective poly(ethylene glycol) coatings via interfacial photopolymerization. Biotechnol Bioeng. 1994 Jul; 44(3):383-6. View in: PubMed

  169. Drumheller PD, Elbert DL, Hubbell JA. Multifunctional poly(ethylene glycol) semi-interpenetrating polymer networks as highly selective adhesive substrates for bioadhesive peptide grafting. Biotechnol Bioeng. 1994 Apr 05; 43(8):772-80. View in: PubMed

  170. Hubbell JA, Palsson BO, Papoutsakis ET. Preface: Tissue engineering and cell therapies: II. Biotechnol Bioeng. 1994 Apr 05; 43(8):683. View in: PubMed

  171. Hubbell JA, Palsson BO, Papoutsakis ET. Preface. Tissue engineering and cell therapies. Biotechnol Bioeng. 1994 Mar 25; 43(7):541. View in: PubMed

  172. Velluto D, Demurtas D, Hubbell JA. PEG-b-PPS diblock copolymer aggregates for hydrophobic drug solubilization and release: cyclosporin A as an example. Mol Pharm. 2008 Jul-Aug; 5(4):632-42. View in: PubMed

  173. Kraehenbuehl TP, Zammaretti P, Van der Vlies AJ, Schoenmakers RG, Lutolf MP, Jaconi ME, Hubbell JA. Three-dimensional extracellular matrix-directed cardioprogenitor differentiation: systematic modulation of a synthetic cell-responsive PEG-hydrogel. Biomaterials. 2008 Jun; 29(18):2757-66. View in: PubMed

  174. Bearinger JP, Stone G, Christian AT, Dugan L, Hiddessen AL, Wu KJ, Wu L, Hamilton J, Stockton C, Hubbell JA. Porphyrin-based photocatalytic lithography. Langmuir. 2008 May 06; 24(9):5179-84. View in: PubMed

  175. Rothenfluh DA, Bermudez H, O'Neil CP, Hubbell JA. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat Mater. 2008 Mar; 7(3):248-54. View in: PubMed

  176. Rehor A, Schmoekel H, Tirelli N, Hubbell JA. Functionalization of polysulfide nanoparticles and their performance as circulating carriers. Biomaterials. 2008 Apr; 29(12):1958-66. View in: PubMed

  177. Tornay R, Braschler T, Demierre N, Steitz B, Finka A, Hofmann H, Hubbell JA, Renaud P. Dielectrophoresis-based particle exchanger for the manipulation and surface functionalization of particles. Lab Chip. 2008 Feb; 8(2):267-73. View in: PubMed

  178. Swartz MA, Hubbell JA, Reddy ST. Lymphatic drainage function and its immunological implications: from dendritic cell homing to vaccine design. Semin Immunol. 2008 Apr; 20(2):147-56. View in: PubMed

  179. Ehrbar M, Zeisberger SM, Raeber GP, Hubbell JA, Schnell C, Zisch AH. The role of actively released fibrin-conjugated VEGF for VEGF receptor 2 gene activation and the enhancement of angiogenesis. Biomaterials. 2008 Apr; 29(11):1720-9. View in: PubMed

  180. Mercanzini A, Reddy S, Velluto D, Colin P, Maillard A, Bensadoun JC, Bertsch A, Hubbell JA, Renaud P. Controlled release drug coatings on flexible neural probes. Annu Int Conf IEEE Eng Med Biol Soc. 2007; 2007:6613-6. View in: PubMed

  181. Adelöw C, Segura T, Hubbell JA, Frey P. The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype. Biomaterials. 2008 Jan; 29(3):314-26. View in: PubMed

  182. Dégano IR, Vilalta M, Bagó JR, Matthies AM, Hubbell JA, Dimitriou H, Bianco P, Rubio N, Blanco J. Bioluminescence imaging of calvarial bone repair using bone marrow and adipose tissue-derived mesenchymal stem cells. Biomaterials. 2008 Feb; 29(4):427-37. View in: PubMed

  183. Ehrbar M, Rizzi SC, Schoenmakers RG, Miguel BS, Hubbell JA, Weber FE, Lutolf MP. Biomolecular hydrogels formed and degraded via site-specific enzymatic reactions. Biomacromolecules. 2007 Oct; 8(10):3000-7. View in: PubMed

  184. Hubbell JA. Matrix-bound growth factors in tissue repair. Swiss Med Wkly. 2007 Mar 02; 137 Suppl 155:72S-76S. View in: PubMed

  185. Reddy ST, van der Vlies AJ, Simeoni E, Angeli V, Randolph GJ, O'Neil CP, Lee LK, Swartz MA, Hubbell JA. Exploiting lymphatic transport and complement activation in nanoparticle vaccines. Nat Biotechnol. 2007 Oct; 25(10):1159-64. View in: PubMed

  186. Raeber GP, Lutolf MP, Hubbell JA. Part II: Fibroblasts preferentially migrate in the direction of principal strain. Biomech Model Mechanobiol. 2008 Jun; 7(3):215-25. View in: PubMed

  187. Raeber GP, Lutolf MP, Hubbell JA. Mechanisms of 3-D migration and matrix remodeling of fibroblasts within artificial ECMs. Acta Biomater. 2007 Sep; 3(5):615-29. View in: PubMed

  188. Ehrbar M, Rizzi SC, Hlushchuk R, Djonov V, Zisch AH, Hubbell JA, Weber FE, Lutolf MP. Enzymatic formation of modular cell-instructive fibrin analogs for tissue engineering. Biomaterials. 2007 Sep; 28(26):3856-66. View in: PubMed

  189. Segura T, Schmokel H, Hubbell JA. RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats. J Surg Res. 2007 Aug; 141(2):162-70. View in: PubMed

  190. Cerritelli S, Velluto D, Hubbell JA. PEG-SS-PPS: reduction-sensitive disulfide block copolymer vesicles for intracellular drug delivery. Biomacromolecules. 2007 Jun; 8(6):1966-72. View in: PubMed

  191. Raeber GP, Mayer J, Hubbell JA. Part I: A novel in-vitro system for simultaneous mechanical stimulation and time-lapse microscopy in 3D. Biomech Model Mechanobiol. 2008 Jun; 7(3):203-14. View in: PubMed

  192. Walpoth BH, Zammaretti P, Cikirikcioglu M, Khabiri E, Djebaili MK, Pache JC, Tille JC, Aggoun Y, Morel D, Kalangos A, Hubbell JA, Zisch AH. Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model. J Thorac Cardiovasc Surg. 2007 May; 133(5):1163-70. View in: PubMed

  193. Segura T, Hubbell JA. Synthesis and in vitro characterization of an ABC triblock copolymer for siRNA delivery. Bioconjug Chem. 2007 May-Jun; 18(3):736-45. View in: PubMed

  194. Román I, Vilalta M, Rodriguez J, Matthies AM, Srouji S, Livne E, Hubbell JA, Rubio N, Blanco J. Analysis of progenitor cell-scaffold combinations by in vivo non-invasive photonic imaging. Biomaterials. 2007 Jun; 28(17):2718-28. View in: PubMed

  195. Kim DH, Haake A, Sun Y, Neild AP, Ihm JE, Dual J, Hubbell JA, Ju BK, Nelson BJ. High-throughput cell manipulation using ultrasound fields. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:2571-4. View in: PubMed

  196. Rizzi SC, Ehrbar M, Halstenberg S, Raeber GP, Schmoekel HG, Hagenmüller H, Müller R, Weber FE, Hubbell JA. Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes. Part II: biofunctional characteristics. Biomacromolecules. 2006 Nov; 7(11):3019-29. View in: PubMed

  197. Reddy ST, Swartz MA, Hubbell JA. Targeting dendritic cells with biomaterials: developing the next generation of vaccines. Trends Immunol. 2006 Dec; 27(12):573-9. View in: PubMed

  198. Billinger M, Buddeberg F, Hubbell JA, Elbert DL, Schaffner T, Mettler D, Windecker S, Meier B, Hess OM. Polymer stent coating for prevention of neointimal hyperplasia. J Invasive Cardiol. 2006 Sep; 18(9):423-6; discussion 427. View in: PubMed

  199. Missirlis D, Kawamura R, Tirelli N, Hubbell JA. Doxorubicin encapsulation and diffusional release from stable, polymeric, hydrogel nanoparticles. Eur J Pharm Sci. 2006 Oct 01; 29(2):120-9. View in: PubMed

  200. Maynard HD, Hubbell JA. Discovery of a sulfated tetrapeptide that binds to vascular endothelial growth factor. Acta Biomater. 2005 Jul; 1(4):451-9. View in: PubMed

  201. Ihm JE, Han KO, Hwang CS, Kang JH, Ahn KD, Han IK, Han DK, Hubbell JA, Cho CS. Poly (4-vinylimidazole) as nonviral gene carrier: in vitro and in vivo transfection. Acta Biomater. 2005 Mar; 1(2):165-72. View in: PubMed

  202. Hubbell JA. Non-viral gene delivery: multifunctional polyplexes as locally triggerable nonviral vectors. Gene Ther. 2006 Oct; 13(19):1371-2. View in: PubMed

  203. Reddy ST, Rehor A, Schmoekel HG, Hubbell JA, Swartz MA. In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles. J Control Release. 2006 May 01; 112(1):26-34. View in: PubMed

  204. Reidy M, Zihlmann P, Hubbell JA, Hall H. Activation of cell-survival transcription factor NFkappaB in L1Ig6-stimulated endothelial cells. J Biomed Mater Res A. 2006 Jun 01; 77(3):542-50. View in: PubMed

  205. Trentin D, Hall H, Wechsler S, Hubbell JA. Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1alpha variant for local induction of angiogenesis. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2506-11. View in: PubMed

  206. Lussi JW, Falconnet D, Hubbell JA, Textor M, Csucs G. Pattern stability under cell culture conditions--a comparative study of patterning methods based on PLL-g-PEG background passivation. Biomaterials. 2006 Apr; 27(12):2534-41. View in: PubMed

  207. Karrer L, Duwe J, Zisch AH, Khabiri E, Cikirikcioglu M, Napoli A, Goessl A, Schaffner T, Hess OM, Carrel T, Kalangos A, Hubbell JA, Walpoth BH. PPS-PEG surface coating to reduce thrombogenicity of small diameter ePTFE vascular grafts. Int J Artif Organs. 2005 Oct; 28(10):993-1002. View in: PubMed

  208. Napoli A, Bermudez H, Hubbell JA. Interfacial reactivity of block copolymers: understanding the amphiphile-to-hydrophile transition. Langmuir. 2005 Sep 27; 21(20):9149-53. View in: PubMed

  209. Thurner P, Müller R, Raeber G, Sennhauser U, Hubbell JA. 3D morphology of cell cultures: a quantitative approach using micrometer synchrotron light tomography. Microsc Res Tech. 2005 Apr 15; 66(6):289-98. View in: PubMed

  210. Meinhart JG, Schense JC, Schima H, Gorlitzer M, Hubbell JA, Deutsch M, Zilla P. Enhanced endothelial cell retention on shear-stressed synthetic vascular grafts precoated with RGD-cross-linked fibrin. Tissue Eng. 2005 May-Jun; 11(5-6):887-95. View in: PubMed

  211. Raeber GP, Lutolf MP, Hubbell JA. Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration. Biophys J. 2005 Aug; 89(2):1374-88. View in: PubMed

  212. Rizzi SC, Hubbell JA. Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes. Part I: Development and physicochemical characteristics. Biomacromolecules. 2005 May-Jun; 6(3):1226-38. View in: PubMed

  213. Napoli A, Boerakker MJ, Tirelli N, Nolte RJ, Sommerdijk NA, Hubbell JA. Glucose-oxidase based self-destructing polymeric vesicles. Langmuir. 2004 Apr 27; 20(9):3487-91. View in: PubMed

  214. Tae G, Kornfield JA, Hubbell JA. Sustained release of human growth hormone from in situ forming hydrogels using self-assembly of fluoroalkyl-ended poly(ethylene glycol). Biomaterials. 2005 Sep; 26(25):5259-66. View in: PubMed

  215. Weber CC, Cai H, Ehrbar M, Kubota H, Martiny-Baron G, Weber W, Djonov V, Weber E, Mallik AS, Fussenegger M, Frei K, Hubbell JA, Zisch AH. Effects of protein and gene transfer of the angiopoietin-1 fibrinogen-like receptor-binding domain on endothelial and vessel organization. J Biol Chem. 2005 Jun 10; 280(23):22445-53. View in: PubMed

  216. Missirlis D, Tirelli N, Hubbell JA. Amphiphilic hydrogel nanoparticles. Preparation, characterization, and preliminary assessment as new colloidal drug carriers. Langmuir. 2005 Mar 15; 21(6):2605-13. View in: PubMed

  217. Schmoekel HG, Weber FE, Hurter K, Schense JC, Seiler G, Ryrz U, Spreng D, Schawalder P, Hubbell J. Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats. J Small Anim Pract. 2005 Jan; 46(1):17-21. View in: PubMed

  218. van de Wetering P, Metters AT, Schoenmakers RG, Hubbell JA. Poly(ethylene glycol) hydrogels formed by conjugate addition with controllable swelling, degradation, and release of pharmaceutically active proteins. J Control Release. 2005 Feb 16; 102(3):619-27. View in: PubMed

  219. Trentin D, Hubbell J, Hall H. Non-viral gene delivery for local and controlled DNA release. J Control Release. 2005 Jan 20; 102(1):263-75. View in: PubMed

  220. Metters A, Hubbell J. Network formation and degradation behavior of hydrogels formed by Michael-type addition reactions. Biomacromolecules. 2005 Jan-Feb; 6(1):290-301. View in: PubMed

  221. Lutolf MP, Hubbell JA. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol. 2005 Jan; 23(1):47-55. View in: PubMed

  222. Rehor A, Hubbell JA, Tirelli N. Oxidation-sensitive polymeric nanoparticles. Langmuir. 2005 Jan 04; 21(1):411-7. View in: PubMed

  223. Schmoekel HG, Weber FE, Schense JC, Grätz KW, Schawalder P, Hubbell JA. Bone repair with a form of BMP-2 engineered for incorporation into fibrin cell ingrowth matrices. Biotechnol Bioeng. 2005 Feb 05; 89(3):253-62. View in: PubMed

  224. Pittier R, Sauthier F, Hubbell JA, Hall H. Neurite extension and in vitro myelination within three-dimensional modified fibrin matrices. J Neurobiol. 2005 Apr; 63(1):1-14. View in: PubMed

  225. Hall H, Djonov V, Ehrbar M, Hoechli M, Hubbell JA. Heterophilic interactions between cell adhesion molecule L1 and alphavbeta3-integrin induce HUVEC process extension in vitro and angiogenesis in vivo. Angiogenesis. 2004; 7(3):213-23. View in: PubMed

  226. Ehrbar M, Metters A, Zammaretti P, Hubbell JA, Zisch AH. Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity. J Control Release. 2005 Jan 03; 101(1-3):93-109. View in: PubMed

  227. Cellesi F, Weber W, Fussenegger M, Hubbell JA, Tirelli N. Towards a fully synthetic substitute of alginate: optimization of a thermal gelation/chemical cross-linking scheme ("tandem" gelation) for the production of beads and liquid-core capsules. Biotechnol Bioeng. 2004 Dec 20; 88(6):740-9. View in: PubMed

  228. Hall H, Hubbell JA. Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2. Microvasc Res. 2004 Nov; 68(3):169-78. View in: PubMed

  229. Urech L, Bittermann AG, Hubbell JA, Hall H. Mechanical properties, proteolytic degradability and biological modifications affect angiogenic process extension into native and modified fibrin matrices in vitro. Biomaterials. 2005 Apr; 26(12):1369-79. View in: PubMed

  230. Hubbell JA. Tissue and cell engineering. Curr Opin Biotechnol. 2004 Oct; 15(5):381-2. View in: PubMed

  231. Goessl A, Tirelli N, Hubbell JA. A hydrogel system for stimulus-responsive, oxygen-sensitive in situ gelation. J Biomater Sci Polym Ed. 2004; 15(7):895-904. View in: PubMed

  232. Hubbell JA. Biomaterials science and high-throughput screening. Nat Biotechnol. 2004 Jul; 22(7):828-9. View in: PubMed

  233. Fittkau MH, Zilla P, Bezuidenhout D, Lutolf MP, Human P, Hubbell JA, Davies N. The selective modulation of endothelial cell mobility on RGD peptide containing surfaces by YIGSR peptides. Biomaterials. 2005 Jan; 26(2):167-74. View in: PubMed

  234. Park Y, Lutolf MP, Hubbell JA, Hunziker EB, Wong M. Bovine primary chondrocyte culture in synthetic matrix metalloproteinase-sensitive poly(ethylene glycol)-based hydrogels as a scaffold for cartilage repair. Tissue Eng. 2004 Mar-Apr; 10(3-4):515-22. View in: PubMed

  235. Cellesi F, Tirelli N, Hubbell JA. Towards a fully-synthetic substitute of alginate: development of a new process using thermal gelation and chemical cross-linking. Biomaterials. 2004 Sep; 25(21):5115-24. View in: PubMed

  236. Ehrbar M, Djonov VG, Schnell C, Tschanz SA, Martiny-Baron G, Schenk U, Wood J, Burri PH, Hubbell JA, Zisch AH. Cell-demanded liberation of VEGF121 from fibrin implants induces local and controlled blood vessel growth. Circ Res. 2004 Apr 30; 94(8):1124-32. View in: PubMed

  237. Schmökel HG, Weber FE, Seiler G, von Rechenberg B, Schense JC, Schawalder P, Hubbell J. Treatment of nonunions with nonglycosylated recombinant human bone morphogenetic protein-2 delivered from a fibrin matrix. Vet Surg. 2004 Mar-Apr; 33(2):112-8. View in: PubMed

  238. Schmoekel H, Schense JC, Weber FE, Grätz KW, Gnägi D, Müller R, Hubbell JA. Bone healing in the rat and dog with nonglycosylated BMP-2 demonstrating low solubility in fibrin matrices. J Orthop Res. 2004 Mar; 22(2):376-81. View in: PubMed

  239. Pratt AB, Weber FE, Schmoekel HG, Müller R, Hubbell JA. Synthetic extracellular matrices for in situ tissue engineering. Biotechnol Bioeng. 2004 Apr 05; 86(1):27-36. View in: PubMed

  240. Napoli A, Valentini M, Tirelli N, Müller M, Hubbell JA. Oxidation-responsive polymeric vesicles. Nat Mater. 2004 Mar; 3(3):183-9. View in: PubMed

  241. Seliktar D, Zisch AH, Lutolf MP, Wrana JL, Hubbell JA. MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. J Biomed Mater Res A. 2004 Mar 15; 68(4):704-16. View in: PubMed

  242. Schoenmakers RG, van de Wetering P, Elbert DL, Hubbell JA. The effect of the linker on the hydrolysis rate of drug-linked ester bonds. J Control Release. 2004 Mar 05; 95(2):291-300. View in: PubMed

  243. Zisch AH, Zeisberger SM, Ehrbar M, Djonov V, Weber CC, Ziemiecki A, Pasquale EB, Hubbell JA. Engineered fibrin matrices for functional display of cell membrane-bound growth factor-like activities: study of angiogenic signaling by ephrin-B2. Biomaterials. 2004 Jul; 25(16):3245-57. View in: PubMed

  244. Valentini M, Vaccaro A, Rehor A, Napoli A, Hubbell JA, Tirelli N. Diffusion NMR spectroscopy for the characterization of the size and interactions of colloidal matter: the case of vesicles and nanoparticles. J Am Chem Soc. 2004 Feb 25; 126(7):2142-7. View in: PubMed

  245. Tosatti S, Schwartz Z, Campbell C, Cochran DL, VandeVondele S, Hubbell JA, Denzer A, Simpson J, Wieland M, Lohmann CH, Textor M, Boyan BD. RGD-containing peptide GCRGYGRGDSPG reduces enhancement of osteoblast differentiation by poly(L-lysine)-graft-poly(ethylene glycol)-coated titanium surfaces. J Biomed Mater Res A. 2004 Mar 01; 68(3):458-72. View in: PubMed

  246. Hall H, Bozic D, Michel K, Hubbell JA. N-terminal alpha-dystroglycan binds to different extracellular matrix molecules expressed in regenerating peripheral nerves in a protein-mediated manner and promotes neurite extension of PC12 cells. Mol Cell Neurosci. 2003 Dec; 24(4):1062-73. View in: PubMed

  247. Zisch AH, Lutolf MP, Hubbell JA. Biopolymeric delivery matrices for angiogenic growth factors. Cardiovasc Pathol. 2003 Nov-Dec; 12(6):295-310. View in: PubMed

  248. Hubbell JA. Materials as morphogenetic guides in tissue engineering. Curr Opin Biotechnol. 2003 Oct; 14(5):551-8. View in: PubMed

  249. Hubbell JA. Tissue and cell engineering. Curr Opin Biotechnol. 2003 Oct; 14(5):517-9. View in: PubMed

  250. Zisch AH, Lutolf MP, Ehrbar M, Raeber GP, Rizzi SC, Davies N, Schmökel H, Bezuidenhout D, Djonov V, Zilla P, Hubbell JA. Cell-demanded release of VEGF from synthetic, biointeractive cell ingrowth matrices for vascularized tissue growth. FASEB J. 2003 Dec; 17(15):2260-2. View in: PubMed

  251. Tosatti S, De Paul SM, Askendal A, VandeVondele S, Hubbell JA, Tengvall P, Textor M. Peptide functionalized poly(L-lysine)-g-poly(ethylene glycol) on titanium: resistance to protein adsorption in full heparinized human blood plasma. Biomaterials. 2003 Dec; 24(27):4949-58. View in: PubMed

  252. Heggli M, Tirelli N, Zisch A, Hubbell JA. Michael-type addition as a tool for surface functionalization. Bioconjug Chem. 2003 Sep-Oct; 14(5):967-73. View in: PubMed

  253. Kusonwiriyawong C, van de Wetering P, Hubbell JA, Merkle HP, Walter E. Evaluation of pH-dependent membrane-disruptive properties of poly(acrylic acid) derived polymers. Eur J Pharm Biopharm. 2003 Sep; 56(2):237-46. View in: PubMed

  254. Lutolf MP, Hubbell JA. Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition. Biomacromolecules. 2003 May-Jun; 4(3):713-22. View in: PubMed

  255. Hubbell JA. Materials science. Enhancing drug function. Science. 2003 Apr 25; 300(5619):595-6. View in: PubMed

  256. Lutolf MP, Weber FE, Schmoekel HG, Schense JC, Kohler T, Müller R, Hubbell JA. Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat Biotechnol. 2003 May; 21(5):513-8. View in: PubMed

  257. VandeVondele S, Vörös J, Hubbell JA. RGD-grafted poly-L-lysine-graft-(polyethylene glycol) copolymers block non-specific protein adsorption while promoting cell adhesion. Biotechnol Bioeng. 2003 Jun 30; 82(7):784-90. View in: PubMed

  258. Bearinger JP, Terrettaz S, Michel R, Tirelli N, Vogel H, Textor M, Hubbell JA. Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions. Nat Mater. 2003 Apr; 2(4):259-64. View in: PubMed

  259. Lutolf MP, Lauer-Fields JL, Schmoekel HG, Metters AT, Weber FE, Fields GB, Hubbell JA. Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5413-8. View in: PubMed

  260. Bearinger JP, Vörös J, Hubbell JA, Textor M. Electrochemical optical waveguide lightmode spectroscopy (EC-OWLS): a pilot study using evanescent-field optical sensing under voltage control to monitor polycationic polymer adsorption onto indium tin oxide (ITO)-coated waveguide chips. Biotechnol Bioeng. 2003 May 20; 82(4):465-73. View in: PubMed

  261. Vernon B, Tirelli N, Bächi T, Haldimann D, Hubbell JA. Water-borne, in situ crosslinked biomaterials from phase-segregated precursors. J Biomed Mater Res A. 2003 Mar 01; 64(3):447-56. View in: PubMed

  262. Park YD, Tirelli N, Hubbell JA. Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks. Biomaterials. 2003 Mar; 24(6):893-900. View in: PubMed

  263. Halstenberg S, Panitch A, Rizzi S, Hall H, Hubbell JA. Biologically engineered protein-graft-poly(ethylene glycol) hydrogels: a cell adhesive and plasmin-degradable biosynthetic material for tissue repair. Biomacromolecules. 2002 Jul-Aug; 3(4):710-23. View in: PubMed

  264. Tirelli N, Lutolf MP, Napoli A, Hubbell JA. Poly(ethylene glycol) block copolymers. J Biotechnol. 2002 Mar; 90(1):3-15. View in: PubMed

  265. Winblade ND, Schmökel H, Baumann M, Hoffman AS, Hubbell JA. Sterically blocking adhesion of cells to biological surfaces with a surface-active copolymer containing poly(ethylene glycol) and phenylboronic acid. J Biomed Mater Res. 2002 Mar 15; 59(4):618-31. View in: PubMed

  266. Elbert DL, Hubbell JA. Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering. Biomacromolecules. 2001; 2(2):430-41. View in: PubMed

  267. Lutolf MP, Tirelli N, Cerritelli S, Cavalli L, Hubbell JA. Systematic modulation of Michael-type reactivity of thiols through the use of charged amino acids. Bioconjug Chem. 2001 Nov-Dec; 12(6):1051-6. View in: PubMed

  268. Winblade ND, Nikolic ID, Hoffman AS, Hubbell JA. Blocking adhesion to cell and tissue surfaces by the chemisorption of a poly-L-lysine-graft-(poly(ethylene glycol); phenylboronic acid) copolymer. Biomacromolecules. 2000; 1(4):523-33. View in: PubMed

  269. Hall H, Baechi T, Hubbell JA. Molecular properties of fibrin-based matrices for promotion of angiogenesis in vitro. Microvasc Res. 2001 Nov; 62(3):315-26. View in: PubMed

  270. Elbert DL, Pratt AB, Lutolf MP, Halstenberg S, Hubbell JA. Protein delivery from materials formed by self-selective conjugate addition reactions. J Control Release. 2001 Sep 11; 76(1-2):11-25. View in: PubMed

  271. Kao WJ, Lee D, Schense JC, Hubbell JA. Fibronectin modulates macrophage adhesion and FBGC formation: the role of RGD, PHSRN, and PRRARV domains. J Biomed Mater Res. 2001 Apr; 55(1):79-88. View in: PubMed

  272. Zisch AH, Schenk U, Schense JC, Sakiyama-Elbert SE, Hubbell JA. Covalently conjugated VEGF--fibrin matrices for endothelialization. J Control Release. 2001 May 14; 72(1-3):101-13. View in: PubMed

  273. Sakiyama-Elbert SE, Panitch A, Hubbell JA. Development of growth factor fusion proteins for cell-triggered drug delivery. FASEB J. 2001 May; 15(7):1300-2. View in: PubMed

  274. Sakiyama-Elbert SE, Hubbell JA. Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix. J Control Release. 2000 Oct 03; 69(1):149-58. View in: PubMed

  275. Ye Q, Zünd G, Benedikt P, Jockenhoevel S, Hoerstrup SP, Sakyama S, Hubbell JA, Turina M. Fibrin gel as a three dimensional matrix in cardiovascular tissue engineering. Eur J Cardiothorac Surg. 2000 May; 17(5):587-91. View in: PubMed

  276. Schense JC, Bloch J, Aebischer P, Hubbell JA. Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension. Nat Biotechnol. 2000 Apr; 18(4):415-9. View in: PubMed

  277. Schense JC, Hubbell JA. Three-dimensional migration of neurites is mediated by adhesion site density and affinity. J Biol Chem. 2000 Mar 10; 275(10):6813-8. View in: PubMed

  278. Sakiyama-Elbert SE, Hubbell JA. Development of fibrin derivatives for controlled release of heparin-binding growth factors. J Control Release. 2000 Apr 03; 65(3):389-402. View in: PubMed

  279. An Y, Hubbell JA. Intraarterial protein delivery via intimally-adherent bilayer hydrogels. J Control Release. 2000 Feb 14; 64(1-3):205-15. View in: PubMed

  280. Barnhart MD, Hubbell JA, Muir WW, Sams RA, Bednarski RM. Pharmacokinetics, pharmacodynamics, and analgesic effects of morphine after rectal, intramuscular, and intravenous administration in dogs. Am J Vet Res. 2000 Jan; 61(1):24-8. View in: PubMed

  281. Sakiyama SE, Schense JC, Hubbell JA. Incorporation of heparin-binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering. FASEB J. 1999 Dec; 13(15):2214-24. View in: PubMed

  282. Cruise GM, Hegre OD, Lamberti FV, Hager SR, Hill R, Scharp DS, Hubbell JA. In vitro and in vivo performance of porcine islets encapsulated in interfacially photopolymerized poly(ethylene glycol) diacrylate membranes. Cell Transplant. 1999 May-Jun; 8(3):293-306. View in: PubMed

  283. Hubbell JA. Bioactive biomaterials. Curr Opin Biotechnol. 1999 Apr; 10(2):123-9. View in: PubMed

  284. Kao WJ, Hubbell JA. Murine macrophage behavior on peptide-grafted polyethyleneglycol-containing networks. Biotechnol Bioeng. 1998 Jul 05; 59(1):2-9. View in: PubMed

  285. Cruise GM, Hegre OD, Scharp DS, Hubbell JA. A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylate upon porcine islets. Biotechnol Bioeng. 1998 Mar 20; 57(6):655-65. View in: PubMed

  286. Hubbell JA. Biotechnology. A new-for-old urinary bladder. Nature. 1999 Mar 18; 398(6724):198-9. View in: PubMed

  287. Lore AB, Hubbell JA, Bobb DS, Ballinger ML, Loftin KL, Smith JW, Smyers ME, Garcia HD, Bittner GD. Rapid induction of functional and morphological continuity between severed ends of mammalian or earthworm myelinated axons. J Neurosci. 1999 Apr 01; 19(7):2442-54. View in: PubMed

  288. Schense JC, Hubbell JA. Cross-linking exogenous bifunctional peptides into fibrin gels with factor XIIIa. Bioconjug Chem. 1999 Jan-Feb; 10(1):75-81. View in: PubMed

  289. Elbert DL, Hubbell JA. Reduction of fibrous adhesion formation by a copolymer possessing an affinity for anionic surfaces. J Biomed Mater Res. 1998 Oct; 42(1):55-65. View in: PubMed

  290. Cruise GM, Scharp DS, Hubbell JA. Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels. Biomaterials. 1998 Jul; 19(14):1287-94. View in: PubMed

  291. Han DK, Park KD, Hubbell JA, Kim YH. Surface characteristics and biocompatibility of lactide-based poly(ethylene glycol) scaffolds for tissue engineering. J Biomater Sci Polym Ed. 1998; 9(7):667-80. View in: PubMed

  292. Noh I, Goodman SL, Hubbell JA. Chemical modification and photograft polymerization upon expanded poly(tetrafluoroethylene). J Biomater Sci Polym Ed. 1998; 9(5):407-26. View in: PubMed

  293. Hubbell JA. Biomaterials in tissue engineering. Biotechnology (N Y). 1995 Jun; 13(6):565-76. View in: PubMed

  294. Hill RS, Cruise GM, Hager SR, Lamberti FV, Yu X, Garufis CL, Yu Y, Mundwiler KE, Cole JF, Hubbell JA, Hegre OD, Scharp DW. Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets. Ann N Y Acad Sci. 1997 Dec 31; 831:332-43. View in: PubMed

  295. Herbert CB, Nagaswami C, Bittner GD, Hubbell JA, Weisel JW. Effects of fibrin micromorphology on neurite growth from dorsal root ganglia cultured in three-dimensional fibrin gels. J Biomed Mater Res. 1998 Jun 15; 40(4):551-9. View in: PubMed

  296. Elbert DL, Hubbell JA. Self-assembly and steric stabilization at heterogeneous, biological surfaces using adsorbing block copolymers. Chem Biol. 1998 Mar; 5(3):177-83. View in: PubMed

  297. Hern DL, Hubbell JA. Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing. J Biomed Mater Res. 1998 Feb; 39(2):266-76. View in: PubMed

  298. Frautschi JR, Eberhart RC, Hubbell JA. Alkylated cellulosic membranes with enhanced albumin affinity: influence of competing proteins. J Biomater Sci Polym Ed. 1995; 7(7):563-75. View in: PubMed

  299. West JL, Hubbell JA. Separation of the arterial wall from blood contact using hydrogel barriers reduces intimal thickening after balloon injury in the rat: the roles of medial and luminal factors in arterial healing. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13188-93. View in: PubMed

  300. Herbert CB, Bittner GD, Hubbell JA. Effects of fibinolysis on neurite growth from dorsal root ganglia cultured in two- and three-dimensional fibrin gels. J Comp Neurol. 1996 Feb 12; 365(3):380-91. View in: PubMed

  301. West JL, Chowdhury SM, Sawhney AS, Pathak CP, Dunn RC, Hubbell JA. Efficacy of adhesion barriers. Resorbable hydrogel, oxidized regenerated cellulose and hyaluronic acid. J Reprod Med. 1996 Mar; 41(3):149-54. View in: PubMed

  302. Chowdhury SM, Hubbell JA. Adhesion prevention with ancrod released via a tissue-adherent hydrogel. J Surg Res. 1996 Feb 15; 61(1):58-64. View in: PubMed

  303. Frautschi JR, Eberhart RC, Hubbell JA, Clark BD, Gelfand JA. Alkylation of cellulosic membranes results in reduced complement activation. J Biomater Sci Polym Ed. 1996; 7(8):707-14. View in: PubMed

  304. West JL, Hubbell JA. Comparison of covalently and physically cross-linked polyethylene glycol-based hydrogels for the prevention of postoperative adhesions in a rat model. Biomaterials. 1995 Oct; 16(15):1153-6. View in: PubMed

  305. Hill-West JL, Dunn RC, Hubbell JA. Local release of fibrinolytic agents for adhesion prevention. J Surg Res. 1995 Dec; 59(6):759-63. View in: PubMed

  306. Massia SP, Rao SS, Hubbell JA. Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin. J Biol Chem. 1993 Apr 15; 268(11):8053-9. View in: PubMed

  307. Sawhney AS, Pathak CP, Hubbell JA. Interfacial photopolymerization of poly(ethylene glycol)-based hydrogels upon alginate-poly(l-lysine) microcapsules for enhanced biocompatibility. Biomaterials. 1993 Oct; 14(13):1008-16. View in: PubMed

  308. Hill-West JL, Chowdhury SM, Sawhney AS, Pathak CP, Dunn RC, Hubbell JA. Prevention of postoperative adhesions in the rat by in situ photopolymerization of bioresorbable hydrogel barriers. Obstet Gynecol. 1994 Jan; 83(1):59-64. View in: PubMed

  309. Sawhney AS, Pathak CP, van Rensburg JJ, Dunn RC, Hubbell JA. Optimization of photopolymerized bioerodible hydrogel properties for adhesion prevention. J Biomed Mater Res. 1994 Jul; 28(7):831-8. View in: PubMed

  310. Hill-West JL, Chowdhury SM, Dunn RC, Hubbell JA. Efficacy of a resorbable hydrogel barrier, oxidized regenerated cellulose, and hyaluronic acid in the prevention of ovarian adhesions in a rabbit model. Fertil Steril. 1994 Sep; 62(3):630-4. View in: PubMed

  311. Hill-West JL, Chowdhury SM, Slepian MJ, Hubbell JA. Inhibition of thrombosis and intimal thickening by in situ photopolymerization of thin hydrogel barriers. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):5967-71. View in: PubMed

  312. Csöregi E, Quinn CP, Schmidtke DW, Lindquist SE, Pishko MV, Ye L, Katakis I, Hubbell JA, Heller A. Design, characterization, and one-point in vivo calibration of a subcutaneously implanted glucose electrode. Anal Chem. 1994 Oct 01; 66(19):3131-8. View in: PubMed

  313. Drumheller PD, Hubbell JA. Polymer networks with grafted cell adhesion peptides for highly biospecific cell adhesive substrates. Anal Biochem. 1994 Nov 01; 222(2):380-8. View in: PubMed

  314. Pathak CP, Sawhney AS, Quinn CP, Hubbell JA. Polyimide-polyethylene glycol block copolymers: synthesis, characterization, and initial evaluation as a biomaterial. J Biomater Sci Polym Ed. 1994; 6(4):313-23. View in: PubMed

  315. Hossainy SF, Hubbell JA. Molecular weight dependence of calcification of polyethylene glycol hydrogels. Biomaterials. 1994 Sep; 15(11):921-5. View in: PubMed

  316. Drumheller PD, Hubbell JA. Densely crosslinked polymer networks of poly(ethylene glycol) in trimethylolpropane triacrylate for cell-adhesion-resistant surfaces. J Biomed Mater Res. 1995 Feb; 29(2):207-15. View in: PubMed

  317. Dumanian GA, Dascombe W, Hong C, Labadie K, Garrett K, Sawhney AS, Pathak CP, Hubbell JA, Johnson PC. A new photopolymerizable blood vessel glue that seals human vessel anastomoses without augmenting thrombogenicity. Plast Reconstr Surg. 1995 Apr; 95(5):901-7. View in: PubMed

  318. Quinn CP, Pathak CP, Heller A, Hubbell JA. Photo-crosslinked copolymers of 2-hydroxyethyl methacrylate, poly(ethylene glycol) tetra-acrylate and ethylene dimethacrylate for improving biocompatibility of biosensors. Biomaterials. 1995 Mar; 16(5):389-96. View in: PubMed

  319. Hubbell JA, McIntire LV. Visualization and analysis of mural thrombogenesis on collagen, polyurethane and nylon. Biomaterials. 1986 Sep; 7(5):354-63. View in: PubMed

  320. Desai NP, Hubbell JA. The short-term blood biocompatibility of poly(hydroxyethyl methacrylate-co-methyl methacrylate) in an in vitro flow system measured by digital videomicroscopy. J Biomater Sci Polym Ed. 1989; 1(2):123-46. View in: PubMed

  321. Massia SP, Hubbell JA. Covalent surface immobilization of Arg-Gly-Asp- and Tyr-Ile-Gly-Ser-Arg-containing peptides to obtain well-defined cell-adhesive substrates. Anal Biochem. 1990 Jun; 187(2):292-301. View in: PubMed

  322. Sawhney AS, Hubbell JA. Rapidly degraded terpolymers of dl-lactide, glycolide, and epsilon-caprolactone with increased hydrophilicity by copolymerization with polyethers. J Biomed Mater Res. 1990 Oct; 24(10):1397-411. View in: PubMed

  323. Massia SP, Hubbell JA. Covalently attached GRGD on polymer surfaces promotes biospecific adhesion of mammalian cells. Ann N Y Acad Sci. 1990; 589:261-70. View in: PubMed

  324. Wagner WR, Hubbell JA. Local thrombin synthesis and fibrin formation in an in vitro thrombosis model result in platelet recruitment and thrombus stabilization on collagen in heparinized blood. J Lab Clin Med. 1990 Nov; 116(5):636-50. View in: PubMed

  325. Desai NP, Hubbell JA. Biological responses to polyethylene oxide modified polyethylene terephthalate surfaces. J Biomed Mater Res. 1991 Jul; 25(7):829-43. View in: PubMed

  326. Desai NP, Hubbell JA. Solution technique to incorporate polyethylene oxide and other water-soluble polymers into surfaces of polymeric biomaterials. Biomaterials. 1991 Mar; 12(2):144-53. View in: PubMed

  327. Massia SP, Hubbell JA. Human endothelial cell interactions with surface-coupled adhesion peptides on a nonadhesive glass substrate and two polymeric biomaterials. J Biomed Mater Res. 1991 Feb; 25(2):223-42. View in: PubMed

  328. Massia SP, Hubbell JA. An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3-mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation. J Cell Biol. 1991 Sep; 114(5):1089-100. View in: PubMed

  329. Massia SP, Hubbell JA. Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS region of plasma fibronectin is mediated by integrin alpha 4 beta 1. J Biol Chem. 1992 Jul 15; 267(20):14019-26. View in: PubMed

  330. Massia SP, Hubbell JA. Immobilized amines and basic amino acids as mimetic heparin-binding domains for cell surface proteoglycan-mediated adhesion. J Biol Chem. 1992 May 15; 267(14):10133-41. View in: PubMed

  331. Sawhney AS, Hubbell JA. Poly(ethylene oxide)-graft-poly(L-lysine) copolymers to enhance the biocompatibility of poly(L-lysine)-alginate microcapsule membranes. Biomaterials. 1992; 13(12):863-70. View in: PubMed

  332. Hossiany SF, Desai NP, Hubbell JA. Avoidance of photoactivation in the epifluorescence video microscopic observation of thrombosis. J Biomed Mater Res. 1992 Nov; 26(11):1535-42. View in: PubMed

  333. Hubbell JA, Massia SP, Drumheller PD. Surface-grafted cell-binding peptides in tissue engineering of the vascular graft. Ann N Y Acad Sci. 1992 Oct 13; 665:253-8. View in: PubMed

  334. Desai NP, Hubbell JA. Tissue response to intraperitoneal implants of polyethylene oxide-modified polyethylene terephthalate. Biomaterials. 1992; 13(8):505-10. View in: PubMed

  335. Desai NP, Hossainy SF, Hubbell JA. Surface-immobilized polyethylene oxide for bacterial repellence. Biomaterials. 1992; 13(7):417-20. View in: PubMed

  336. Hubbell JA, Massia SP, Desai NP, Drumheller PD. Endothelial cell-selective materials for tissue engineering in the vascular graft via a new receptor. Biotechnology (N Y). 1991 Jun; 9(6):568-72. View in: PubMed

  337. Massia SP, Hubbell JA. Tissue engineering in the vascular graft. Cytotechnology. 1992; 10(3):189-204. View in: PubMed