Albert Bendelac

Research Summary
Our laboratory studies the populations of lymphocytes that reside at mucosal barriers and perform rapid innate-like functions to maintain homeostasis and protect against infection, injury and tumor. We use developmental biology and genetic engineering to define the identity and track the function of multiple ‘unconventional’ populations including NKT cells, MAIT cells, gamma-delta T cells, innate lymphoid cells, intraepithelial intestinal T lymphocytes and IgA producing intestinal B cells. Ultimately, these studies help identify the central relationships between immunity and microbiome at the intestinal barrier.
Keywords
Innate lymphocytes, T cells, B cells, Lymphocyte development, Microbiome, NKT cells, Intestinal IgA B cells, Intestinal intraepithelial T cells
Education
  • University Paris VI, Paris, France, MD Medicine 06/1985
  • University Paris VII, Paris, France, PhD Immunology 06/1992
Biosciences Graduate Program Association
Awards & Honors
  • 1988 - Gold Medal of the Residency Program Assistance Publique Hopitaux de Paris
  • 1988 - Oulmont, Laval, Dreyfous Prize Academie of Medicine Paris
  • 1994 - 1997 Mallinkrodt Foundation Award
  • 1995 - 1998 Cancer Research Institute Investigator Award
  • 2005 - 2013 Howard Hughes Medical Investigator
  • 2008 - pres A.N. Pritzker Professorship University of Chicago
  • 2017 - MERIT Award National Institutes of Health
  • 2019 - Quantrell Teaching Award University of Chicago
Publications
  1. Bunker JJ, Drees C, Watson AR, Plunkett CH, Nagler CR, Schneewind O, Eren AM, Bendelac A. B cell superantigens in the human intestinal microbiota. Sci Transl Med. 2019 Aug 28; 11(507). View in: PubMed

  2. Bunker JJ, Bendelac A. IgA Responses to Microbiota. Immunity. 2018 08 21; 49(2):211-224. View in: PubMed

  3. McDonald BD, Jabri B, Bendelac A. Diverse developmental pathways of intestinal intraepithelial lymphocytes. Nat Rev Immunol. 2018 08; 18(8):514-525. View in: PubMed

  4. Mao AP, Ishizuka IE, Kasal DN, Mandal M, Bendelac A. Publisher Correction: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017 11 30; 8(1):1933. View in: PubMed

  5. McKnight CG, Morris SC, Perkins C, Zhu Z, Hildeman DA, Bendelac A, Finkelman FD. NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma. PLoS One. 2017; 12(11):e0188221. View in: PubMed

  6. Mao AP, Ishizuka IE, Kasal DN, Mandal M, Bendelac A. A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017 10 16; 8(1):863. View in: PubMed

  7. Bunker JJ, Erickson SA, Flynn TM, Henry C, Koval JC, Meisel M, Jabri B, Antonopoulos DA, Wilson PC, Bendelac A. Natural polyreactive IgA antibodies coat the intestinal microbiota. Science. 2017 10 20; 358(6361). View in: PubMed

  8. Mao AP, Constantinides MG, Mathew R, Zuo Z, Chen X, Weirauch MT, Bendelac A. Multiple layers of transcriptional regulation by PLZF in NKT-cell development. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7602-7. View in: PubMed

  9. Ishizuka IE, Constantinides MG, Gudjonson H, Bendelac A. The Innate Lymphoid Cell Precursor. Annu Rev Immunol. 2016 05 20; 34:299-316. View in: PubMed

  10. Ishizuka IE, Chea S, Gudjonson H, Constantinides MG, Dinner AR, Bendelac A, Golub R. Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage. Nat Immunol. 2016 Mar; 17(3):269-76. View in: PubMed

  11. Verhoef PA, Constantinides MG, McDonald BD, Urban JF, Sperling AI, Bendelac A. Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice. J Allergy Clin Immunol. 2016 Feb; 137(2):591-600.e1. View in: PubMed

  12. McDonald BD, Bunker JJ, Erickson SA, Oh-Hora M, Bendelac A. Crossreactive aß T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection. Immunity. 2015 Nov 17; 43(5):859-69. View in: PubMed

  13. Bunker JJ, Flynn TM, Koval JC, Shaw DG, Meisel M, McDonald BD, Ishizuka IE, Dent AL, Wilson PC, Jabri B, Antonopoulos DA, Bendelac A. Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A. Immunity. 2015 Sep 15; 43(3):541-53. View in: PubMed

  14. Kain L, Costanzo A, Webb B, Holt M, Bendelac A, Savage PB, Teyton L. Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides. Mol Immunol. 2015 Dec; 68(2 Pt A):94-7. View in: PubMed

  15. Constantinides MG, Gudjonson H, McDonald BD, Ishizuka IE, Verhoef PA, Dinner AR, Bendelac A. PLZF expression maps the early stages of ILC1 lineage development. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5123-8. View in: PubMed

  16. Kain L, Webb B, Anderson BL, Deng S, Holt M, Costanzo A, Constanzo A, Zhao M, Self K, Teyton A, Everett C, Kronenberg M, Zajonc DM, Bendelac A, Savage PB, Teyton L. The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian a-linked glycosylceramides. Immunity. 2014 Oct 16; 41(4):543-54. View in: PubMed

  17. Tefit JN, Crabé S, Orlandini B, Nell H, Bendelac A, Deng S, Savage PB, Teyton L, Serra V. Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination. Vaccine. 2014 Oct 21; 32(46):6138-45. View in: PubMed

  18. McDonald BD, Bunker JJ, Ishizuka IE, Jabri B, Bendelac A. Elevated T cell receptor signaling identifies a thymic precursor to the TCRaß(+)CD4(-)CD8ß(-) intraepithelial lymphocyte lineage. Immunity. 2014 Aug 21; 41(2):219-29. View in: PubMed

  19. Mathew R, Mao AP, Chiang AH, Bertozzi-Villa C, Bunker JJ, Scanlon ST, McDonald BD, Constantinides MG, Hollister K, Singer JD, Dent AL, Dinner AR, Bendelac A. A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation. J Exp Med. 2014 Jun 02; 211(6):1137-51. View in: PubMed

  20. Constantinides MG, McDonald BD, Verhoef PA, Bendelac A. A committed precursor to innate lymphoid cells. Nature. 2014 Apr 17; 508(7496):397-401. View in: PubMed

  21. Anderson BL, Teyton L, Bendelac A, Savage PB. Stimulation of natural killer T cells by glycolipids. Molecules. 2013 Dec 16; 18(12):15662-88. View in: PubMed

  22. Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ. Crystal structure of Vd1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human ?d T cells. Immunity. 2013 Dec 12; 39(6):1032-42. View in: PubMed

  23. McDonald BD, Constantinides MG, Bendelac A. Polarized effector programs for innate-like thymocytes. Nat Immunol. 2013 Nov; 14(11):1110-1. View in: PubMed

  24. Bai L, Deng S, Reboulet R, Mathew R, Teyton L, Savage PB, Bendelac A. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):16097-102. View in: PubMed

  25. Zheng Y, Zha Y, Spaapen RM, Mathew R, Barr K, Bendelac A, Gajewski TF. Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy. Mol Immunol. 2013 Oct; 55(3-4):283-91. View in: PubMed

  26. Constantinides MG, Bendelac A. Transcriptional regulation of the NKT cell lineage. Curr Opin Immunol. 2013 Apr; 25(2):161-7. View in: PubMed

  27. Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A. BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Nature. 2012 Nov 22; 491(7425):618-21. View in: PubMed

  28. Freigang S, Landais E, Zadorozhny V, Kain L, Yoshida K, Liu Y, Deng S, Palinski W, Savage PB, Bendelac A, Teyton L. Scavenger receptors target glycolipids for natural killer T cell activation. J Clin Invest. 2012 Nov; 122(11):3943-54. View in: PubMed

  29. Bai L, Picard D, Anderson B, Chaudhary V, Luoma A, Jabri B, Adams EJ, Savage PB, Bendelac A. The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vd1 TCR. Eur J Immunol. 2012 Sep; 42(9):2505-10. View in: PubMed

  30. Bai L, Constantinides MG, Thomas SY, Reboulet R, Meng F, Koentgen F, Teyton L, Savage PB, Bendelac A. Distinct APCs explain the cytokine bias of a-galactosylceramide variants in vivo. J Immunol. 2012 Apr 01; 188(7):3053-61. View in: PubMed

  31. Seiler MP, Mathew R, Liszewski MK, Spooner CJ, Spooner C, Barr K, Meng F, Singh H, Bendelac A. Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling. Nat Immunol. 2012 Feb 05; 13(3):264-71. View in: PubMed

  32. Kammertoens T, Qin Z, Briesemeister D, Bendelac A, Blankenstein T. B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-a, perforin). Int J Cancer. 2012 Oct 01; 131(7):1499-508. View in: PubMed

  33. Scanlon ST, Thomas SY, Ferreira CM, Bai L, Krausz T, Savage PB, Bendelac A. Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation. J Exp Med. 2011 Sep 26; 208(10):2113-24. View in: PubMed

  34. Deng S, Mattner J, Zang Z, Bai L, Teyton L, Bendelac A, Savage PB. Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids. Org Biomol Chem. 2011 Oct 26; 9(22):7659-62. View in: PubMed

  35. Constantinides MG, Picard D, Savage AK, Bendelac A. A naive-like population of human CD1d-restricted T cells expressing intermediate levels of promyelocytic leukemia zinc finger. J Immunol. 2011 Jul 01; 187(1):309-15. View in: PubMed

  36. Thomas SY, Scanlon ST, Griewank KG, Constantinides MG, Savage AK, Barr KA, Meng F, Luster AD, Bendelac A. PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J Exp Med. 2011 Jun 06; 208(6):1179-88. View in: PubMed

  37. Savage AK, Constantinides MG, Bendelac A. Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling. J Immunol. 2011 May 15; 186(10):5801-6. View in: PubMed

  38. Wang L, Carr T, Xiong Y, Wildt KF, Zhu J, Feigenbaum L, Bendelac A, Bosselut R. The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur J Immunol. 2010 Sep; 40(9):2385-90. View in: PubMed

  39. Verykokakis M, Boos MD, Bendelac A, Kee BL. SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics. Immunity. 2010 Aug 27; 33(2):203-15. View in: PubMed

  40. Freigang S, Zadorozhny V, McKinney MK, Krebs P, Herro R, Pawlak J, Kain L, Schrantz N, Masuda K, Liu Y, Savage PB, Bendelac A, Cravatt BF, Teyton L. Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice. J Clin Invest. 2010 Jun; 120(6):1873-84. View in: PubMed

  41. Verykokakis M, Boos MD, Bendelac A, Adams EJ, Pereira P, Kee BL. Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells. PLoS One. 2010 Feb 19; 5(2):e9303. View in: PubMed

  42. Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12453-8. View in: PubMed

  43. Bai L, Sagiv Y, Liu Y, Freigang S, Yu KO, Teyton L, Porcelli SA, Savage PB, Bendelac A. Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer. Proc Natl Acad Sci U S A. 2009 Jun 23; 106(25):10254-9. View in: PubMed

  44. Dose M, Sleckman BP, Han J, Bredemeyer AL, Bendelac A, Gounari F. Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8641-6. View in: PubMed

  45. Yin N, Long X, Goff RD, Zhou D, Cantu C, Mattner J, Mezard PS, Teyton L, Bendelac A, Savage PB. Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells. ACS Chem Biol. 2009 Mar 20; 4(3):199-208. View in: PubMed

  46. Savage AK, Constantinides MG, Han J, Picard D, Martin E, Li B, Lantz O, Bendelac A. The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity. 2008 Sep 19; 29(3):391-403. View in: PubMed

  47. Mattner J, Savage PB, Leung P, Oertelt SS, Wang V, Trivedi O, Scanlon ST, Pendem K, Teyton L, Hart J, Ridgway WM, Wicker LS, Gershwin ME, Bendelac A. Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host Microbe. 2008 May 15; 3(5):304-15. View in: PubMed

  48. Zajonc DM, Savage PB, Bendelac A, Wilson IA, Teyton L. Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids. J Mol Biol. 2008 Apr 04; 377(4):1104-16. View in: PubMed

  49. Liu Y, Deng S, Bai L, Freigang S, Mattner J, Teyton L, Bendelac A, Savage PB. Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties. Bioorg Med Chem Lett. 2008 May 15; 18(10):3052-5. View in: PubMed

  50. Li Y, Teneberg S, Thapa P, Bendelac A, Levery SB, Zhou D. Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry. Glycobiology. 2008 Feb; 18(2):158-65. View in: PubMed

  51. Griewank K, Borowski C, Rietdijk S, Wang N, Julien A, Wei DG, Mamchak AA, Terhorst C, Bendelac A. Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity. 2007 Nov; 27(5):751-62. View in: PubMed

  52. Allende ML, Zhou D, Kalkofen DN, Benhamed S, Tuymetova G, Borowski C, Bendelac A, Proia RL. S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues. FASEB J. 2008 Jan; 22(1):307-15. View in: PubMed

  53. Long X, Deng S, Mattner J, Zang Z, Zhou D, McNary N, Goff RD, Teyton L, Bendelac A, Savage PB. Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids. Nat Chem Biol. 2007 Sep; 3(9):559-64. View in: PubMed

  54. Sagiv Y, Bai L, Wei DG, Agami R, Savage PB, Teyton L, Bendelac A. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med. 2007 Apr 16; 204(4):921-8. View in: PubMed

  55. Schrantz N, Sagiv Y, Liu Y, Savage PB, Bendelac A, Teyton L. The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells. J Exp Med. 2007 Apr 16; 204(4):841-52. View in: PubMed

  56. Novak J, Beaudoin L, Park S, Griseri T, Teyton L, Bendelac A, Lehuen A. Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression. J Immunol. 2007 Feb 01; 178(3):1332-40. View in: PubMed

  57. Zullo AJ, Benlagha K, Bendelac A, Taparowsky EJ. Sensitivity of NK1.1-negative NKT cells to transgenic BATF defines a role for activator protein-1 in the expansion and maturation of immature NKT cells in the thymus. J Immunol. 2007 Jan 01; 178(1):58-66. View in: PubMed

  58. Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol. 2007; 25:297-336. View in: PubMed

  59. Savage PB, Teyton L, Bendelac A. Glycolipids for natural killer T cells. Chem Soc Rev. 2006 Sep; 35(9):771-9. View in: PubMed

  60. Sagiv Y, Hudspeth K, Mattner J, Schrantz N, Stern RK, Zhou D, Savage PB, Teyton L, Bendelac A. Cutting edge: impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein. J Immunol. 2006 Jul 01; 177(1):26-30. View in: PubMed

  61. Wei DG, Curran SA, Savage PB, Teyton L, Bendelac A. Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition. J Exp Med. 2006 May 15; 203(5):1197-207. View in: PubMed

  62. Liu Y, Goff RD, Zhou D, Mattner J, Sullivan BA, Khurana A, Cantu C, Ravkov EV, Ibegbu CC, Altman JD, Teyton L, Bendelac A, Savage PB. A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells. J Immunol Methods. 2006 May 30; 312(1-2):34-9. View in: PubMed

  63. Benlagha K, Wei DG, Veiga J, Teyton L, Bendelac A. Characterization of the early stages of thymic NKT cell development. J Exp Med. 2005 Aug 15; 202(4):485-92. View in: PubMed

  64. Wei DG, Lee H, Park SH, Beaudoin L, Teyton L, Lehuen A, Bendelac A. Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes. J Exp Med. 2005 Jul 18; 202(2):239-48. View in: PubMed

  65. Zajonc DM, Cantu C, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005 Aug; 6(8):810-8. View in: PubMed

  66. Egawa T, Eberl G, Taniuchi I, Benlagha K, Geissmann F, Hennighausen L, Bendelac A, Littman DR. Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity. 2005 Jun; 22(6):705-16. View in: PubMed

  67. Mattner J, Debord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, Savage PB, Bendelac A. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature. 2005 Mar 24; 434(7032):525-9. View in: PubMed

  68. Borowski C, Bendelac A. Signaling for NKT cell development: the SAP-FynT connection. J Exp Med. 2005 Mar 21; 201(6):833-6. View in: PubMed

  69. Bach JF, Bendelac A, Brenner MB, Cantor H, De Libero G, Kronenberg M, Lanier LL, Raulet DH, Shlomchik MJ, von Herrath MG. The role of innate immunity in autoimmunity. J Exp Med. 2004 Dec 20; 200(12):1527-31. View in: PubMed

  70. Zhou D, Mattner J, Cantu C, Schrantz N, Yin N, Gao Y, Sagiv Y, Hudspeth K, Wu YP, Yamashita T, Teneberg S, Wang D, Proia RL, Levery SB, Savage PB, Teyton L, Bendelac A. Lysosomal glycosphingolipid recognition by NKT cells. Science. 2004 Dec 03; 306(5702):1786-9. View in: PubMed

  71. Goff RD, Gao Y, Mattner J, Zhou D, Yin N, Cantu C, Teyton L, Bendelac A, Savage PB. Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. J Am Chem Soc. 2004 Oct 27; 126(42):13602-3. View in: PubMed

  72. Bendelac A. Nondeletional pathways for the development of autoreactive thymocytes. Nat Immunol. 2004 Jun; 5(6):557-8. View in: PubMed

  73. Benlagha K, Park SH, Guinamard R, Forestier C, Karlsson L, Chang CH, Bendelac A. Mechanisms governing B cell developmental defects in invariant chain-deficient mice. J Immunol. 2004 Feb 15; 172(4):2076-83. View in: PubMed

  74. Zhou D, Cantu C, Sagiv Y, Schrantz N, Kulkarni AB, Qi X, Mahuran DJ, Morales CR, Grabowski GA, Benlagha K, Savage P, Bendelac A, Teyton L. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science. 2004 Jan 23; 303(5657):523-7. View in: PubMed

  75. Forestier C, Park SH, Wei D, Benlagha K, Teyton L, Bendelac A. T cell development in mice expressing CD1d directed by a classical MHC class II promoter. J Immunol. 2003 Oct 15; 171(8):4096-104. View in: PubMed

  76. Cantu C, Benlagha K, Savage PB, Bendelac A, Teyton L. The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs. J Immunol. 2003 May 01; 170(9):4673-82. View in: PubMed

  77. Park SH, Kyin T, Bendelac A, Carnaud C. The contribution of NKT cells, NK cells, and other gamma-chain-dependent non-T non-B cells to IL-12-mediated rejection of tumors. J Immunol. 2003 Feb 01; 170(3):1197-201. View in: PubMed

  78. Honey K, Benlagha K, Beers C, Forbush K, Teyton L, Kleijmeer MJ, Rudensky AY, Bendelac A. Thymocyte expression of cathepsin L is essential for NKT cell development. Nat Immunol. 2002 Nov; 3(11):1069-74. View in: PubMed

  79. Procópio DO, Almeida IC, Torrecilhas AC, Cardoso JE, Teyton L, Travassos LR, Bendelac A, Gazzinelli RT. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins from Trypanosoma cruzi bind to CD1d but do not elicit dominant innate or adaptive immune responses via the CD1d/NKT cell pathway. J Immunol. 2002 Oct 01; 169(7):3926-33. View in: PubMed

  80. Lee PT, Putnam A, Benlagha K, Teyton L, Gottlieb PA, Bendelac A. Testing the NKT cell hypothesis of human IDDM pathogenesis. J Clin Invest. 2002 Sep; 110(6):793-800. View in: PubMed

  81. Bendelac A, Teyton L, Savage PB. Lipid presentation by CD1: the short and the long lipid story. Nat Immunol. 2002 May; 3(5):421-2. View in: PubMed

  82. Benlagha K, Kyin T, Beavis A, Teyton L, Bendelac A. A thymic precursor to the NK T cell lineage. Science. 2002 Apr 19; 296(5567):553-5. View in: PubMed

  83. Zhou XT, Forestier C, Goff RD, Li C, Teyton L, Bendelac A, Savage PB. Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6"-amino-6"-deoxy-galactosylceramides. Org Lett. 2002 Apr 18; 4(8):1267-70. View in: PubMed

  84. Bendelac A, Bonneville M, Kearney JF. Autoreactivity by design: innate B and T lymphocytes. Nat Rev Immunol. 2001 Dec; 1(3):177-86. View in: PubMed

  85. Bendelac A, Medzhitov R. Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med. 2002 Mar 04; 195(5):F19-23. View in: PubMed

  86. Lee PT, Benlagha K, Teyton L, Bendelac A. Distinct functional lineages of human V(alpha)24 natural killer T cells. J Exp Med. 2002 Mar 04; 195(5):637-41. View in: PubMed

  87. Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001 Dec; 15(6):897-908. View in: PubMed

  88. Oliveira SA, Park SH, Lee P, Bendelac A, Shenk TE. Murine cytomegalovirus m02 gene family protects against natural killer cell-mediated immune surveillance. J Virol. 2002 Jan; 76(2):885-94. View in: PubMed

  89. Chiu YH, Park SH, Benlagha K, Forestier C, Jayawardena-Wolf J, Savage PB, Teyton L, Bendelac A. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d. Nat Immunol. 2002 Jan; 3(1):55-60. View in: PubMed

  90. Dokun AO, Chu DT, Yang L, Bendelac AS, Yokoyama WM. Analysis of in situ NK cell responses during viral infection. J Immunol. 2001 Nov 01; 167(9):5286-93. View in: PubMed

  91. Park SH, Weiss A, Benlagha K, Kyin T, Teyton L, Bendelac A. The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families. J Exp Med. 2001 Apr 16; 193(8):893-904. View in: PubMed

  92. Park SH, Bendelac A. CD1-restricted T-cell responses and microbial infection. Nature. 2000 Aug 17; 406(6797):788-92. View in: PubMed

  93. Benlagha K, Weiss A, Beavis A, Teyton L, Bendelac A. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J Exp Med. 2000 Jun 05; 191(11):1895-903. View in: PubMed

  94. Park SH, Benlagha K, Lee D, Balish E, Bendelac A. Unaltered phenotype, tissue distribution and function of Valpha14(+) NKT cells in germ-free mice. Eur J Immunol. 2000 Feb; 30(2):620-5. View in: PubMed

  95. Carnaud C, Lee D, Donnars O, Park SH, Beavis A, Koezuka Y, Bendelac A. Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol. 1999 Nov 01; 163(9):4647-50. View in: PubMed

  96. Park SH, Guy-Grand D, Lemonnier FA, Wang CR, Bendelac A, Jabri B. Selection and expansion of CD8alpha/alpha(1) T cell receptor alpha/beta(1) intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules. J Exp Med. 1999 Sep 20; 190(6):885-90. View in: PubMed

  97. Tilloy F, Treiner E, Park SH, Garcia C, Lemonnier F, de la Salle H, Bendelac A, Bonneville M, Lantz O. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J Exp Med. 1999 Jun 21; 189(12):1907-21. View in: PubMed

  98. Chiu YH, Jayawardena J, Weiss A, Lee D, Park SH, Dautry-Varsat A, Bendelac A. Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments. J Exp Med. 1999 Jan 04; 189(1):103-10. View in: PubMed

  99. Park SH, Chiu YH, Jayawardena J, Roark J, Kavita U, Bendelac A. Innate and adaptive functions of the CD1 pathway of antigen presentation. Semin Immunol. 1998 Oct; 10(5):391-8. View in: PubMed

  100. Park SH, Roark JH, Bendelac A. Tissue-specific recognition of mouse CD1 molecules. J Immunol. 1998 Apr 01; 160(7):3128-34. View in: PubMed

  101. Roark JH, Park SH, Jayawardena J, Kavita U, Shannon M, Bendelac A. CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells. J Immunol. 1998 Apr 01; 160(7):3121-7. View in: PubMed

  102. Bendelac A, Rivera MN, Park SH, Roark JH. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu Rev Immunol. 1997; 15:535-62. View in: PubMed

  103. Bendelac A, Hunziker RD, Lantz O. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J Exp Med. 1996 Oct 01; 184(4):1285-93. View in: PubMed

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