We are a multidisciplinary team whose focus is to better understand how mucosal immune responses are dysregulated in the context of intestinal inflammatory disorders. We are particularly intrigued by B lymphocytes that can display many roles beyond antibodies production and can contribute to the pathogenesis of many autoimmune disorders. To get a better understanding of the role played by B lymphocytes in the context of Celiac Disease, we combined mouse and human studies to characterize those cells in health and disease and assess their function.
A Mouse Model of Celiac Disease.
A Mouse Model of Celiac Disease. Curr Protoc. 2022 Aug; 2(8):e515.
PMID: 35994521
Prostaglandin E2 amplifies IL-17 production by ?d T cells during barrier inflammation.
Prostaglandin E2 amplifies IL-17 production by ?d T cells during barrier inflammation. Cell Rep. 2021 07 27; 36(4):109456.
PMID: 34320346
Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease.
Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease. Front Immunol. 2021; 12:674313.
PMID: 34149709
B Lymphocytes Contribute to Celiac Disease Pathogenesis.
B Lymphocytes Contribute to Celiac Disease Pathogenesis. Gastroenterology. 2021 06; 160(7):2608-2610.e4.
PMID: 33667487
[A new mouse model of coeliac disease with villous atrophy].
[A new mouse model of coeliac disease with villous atrophy]. Med Sci (Paris). 2020 Nov; 36(11):969-972.
PMID: 33151855
IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease.
IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease. Nature. 2020 02; 578(7796):600-604.
PMID: 32051586
Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.
Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017 04 07; 356(6333):44-50.
PMID: 28386004
IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction.
IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction. Nat Rev Immunol. 2015 12; 15(12):771-83.
PMID: 26567920
Cysteinyl leukotrienes mediate lymphokine killer activity induced by NKG2D and IL-15 in cytotoxic T cells during celiac disease.
Cysteinyl leukotrienes mediate lymphokine killer activity induced by NKG2D and IL-15 in cytotoxic T cells during celiac disease. J Exp Med. 2015 Sep 21; 212(10):1487-95.
PMID: 26304964
Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease.
Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease. Gastroenterology. 2015 Sep; 149(3):681-91.e10.
PMID: 26001928