Our research aims to uncover the grammar – or general rules – governing how successful immune responses work to stop an infection or remove diseased cells while keeping the host healthy at the end of the process. We emphasize a multiscale approach that parallels the organization of the immune system across the body from molecules and cells to tissues to the whole organism. By creating new tools and approaches, we study how interactions occur between immunological components across these scales to uncover fundamental concepts in immunology and beyond. We pursue this goal in the hope that it will contribute knowledge to the longstanding question of how to manipulate the immune system at will.
Harvard Medical School
Boston, USA
Ph.D. - Immunology
2012
Université de la Méditerranée
Marseille, France
M.S. - Biochemistry, Immunology
2007
Université de Bourgogne
Dijon, France
B.S. - Biochemistry
2005
A pairwise cytokine code explains the organism-wide response to sepsis.
A pairwise cytokine code explains the organism-wide response to sepsis. Nat Immunol. 2024 Feb; 25(2):226-239.
PMID: 38191855
Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation.
Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation. bioRxiv. 2023 Feb 02.
PMID: 36778287
Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids unveils masked epitopes in live neurons.
Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids unveils masked epitopes in live neurons. Nat Commun. 2021 11 18; 12(1):6715.
PMID: 34795271
Pairwise Stimulations of Pathogen-Sensing Pathways Predict Immune Responses to Multi-adjuvant Combinations.
Pairwise Stimulations of Pathogen-Sensing Pathways Predict Immune Responses to Multi-adjuvant Combinations. Cell Syst. 2020 11 18; 11(5):495-508.e10.
PMID: 33113356
A whole-tissue RNA-seq toolkit for organism-wide studies of gene expression with PME-seq.
A whole-tissue RNA-seq toolkit for organism-wide studies of gene expression with PME-seq. Nat Protoc. 2020 04; 15(4):1459-1483.
PMID: 32076350
Decoding the Body Language of Immunity: Tackling the Immune System at the Organism Level.
Decoding the Body Language of Immunity: Tackling the Immune System at the Organism Level. Curr Opin Syst Biol. 2019 Dec; 18:19-26.
PMID: 32490290
Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues.
Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues. Cell. 2017 Oct 05; 171(2):398-413.e21.
PMID: 28942919
An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling.
An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Cell Rep. 2017 06 27; 19(13):2853-2866.
PMID: 28658630
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function.
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016 Dec; 17(12):1436-1446.
PMID: 27695002
Parsing the Interferon Transcriptional Network and Its Disease Associations.
Parsing the Interferon Transcriptional Network and Its Disease Associations. Cell. 2016 Jan 28; 164(3):564-78.
PMID: 26824662