We are a multidisciplinary team with a passion for understanding immune T-cell responses in health and diseases. We study Tregs, unique cells in our body that specialize in preventing autoimmune diseases. We take the unique perspective to look at cellular interactions, i.e. how Tregs talk to other cells to do maintain tolerance, promote tissue homeostasis, and contribute to pathogenesis. We explore the role of Tregs directly in human tissues using Systems and Synthetic Biology approaches that illuminate these interactions.
Inflammatory genital strain of Chlamydia trachomatis elicits a Th17 immune response.
Inflammatory genital strain of Chlamydia trachomatis elicits a Th17 immune response. J Immunol. 2026 Jun 07; 215(6).
PMID: 42413199
Diverse Microbial Exposure Enhances CD8+ T Cell Effector Memory Output and Function.
Diverse Microbial Exposure Enhances CD8+ T Cell Effector Memory Output and Function. bioRxiv. 2026 Feb 04.
PMID: 41676686
The CD8 immgenT framework as a universal reference of mouse CD8aß T cell differentiation states.
The CD8 immgenT framework as a universal reference of mouse CD8aß T cell differentiation states. bioRxiv. 2026 Feb 04.
PMID: 41676596
Epidermal resident memory T cell fitness requires antigen encounter in the skin.
Epidermal resident memory T cell fitness requires antigen encounter in the skin. Elife. 2025 Dec 30; 14.
PMID: 41468295
Unconventional CD8+ T cell surveillance of cytomegalovirus via Qa-1/HLA-E-restricted epitope recognition.
Unconventional CD8+ T cell surveillance of cytomegalovirus via Qa-1/HLA-E-restricted epitope recognition. Sci Adv. 2025 12 19; 11(51):eaea8707.
PMID: 41417899
Mutational signature analysis of chronic lymphocytic leukemia uncovering genomic patterns and prognostic implications.
Mutational signature analysis of chronic lymphocytic leukemia uncovering genomic patterns and prognostic implications. Am J Clin Pathol. 2025 10 04; 164(4):530-544.
PMID: 40814292
Genomic specificity of anti-mouse TCR mAbs determined by single-cell RNAseq.
Genomic specificity of anti-mouse TCR mAbs determined by single-cell RNAseq. J Immunol. 2025 Sep 01; 214(9):2202-2210.
PMID: 40751448
Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin.
Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin. bioRxiv. 2025 Jul 09.
PMID: 40236062
Histopathologic Evaluation and Single-cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients With Inflammatory Bowel Disease.
Histopathologic Evaluation and Single-cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients With Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol. 2025; 19(10):101563.
PMID: 40571096
Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease.
Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease. bioRxiv. 2025 Jan 28.
PMID: 39974918